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Usual Dosing (Adults)

Savella is indicated for the management of fibromyalgia.
Savella is not approved for use in pediatric patients.

Savella is given orally with or without food.
Taking Savella with food may improve the tolerability of the drug.

Recommended Dosing:
The recommended dose of Savella is 100 mg/day (50 mg twice daily).

Based on efficacy and tolerability dosing may be titrated according to the following schedule:
Day 1: 12.5 mg once
Days 2-3: 25 mg/day (12.5 mg twice daily)
Days 4-7: 50 mg/day (25 mg twice daily)
After Day 7: 100 mg/day (50 mg twice daily)

Based on individual patient response, the dose may be increased to 200 mg/day (100 mg twice daily).
Doses above 200 mg/day have not been studied.

Savella should be tapered and not abruptly discontinued after extended use.

Renal Dosing

dialysis Patients with Renal Insufficiency:
No dosage adjustment is necessary in patients with mild renal impairment.

Savella should be used with caution in patients with moderate renal impairment.

For patients with severe renal impairment (indicated by an estimated creatinine clearance of 5-29 mL/min), the maintenance dose should be reduced by 50% to 50 mg/day (25 mg twice daily).

Based on individual patient response, the dose may be increased to 100 mg/day (50 mg twice daily).

End-stage renal disease or Hemodialysis

dialysis Savella is not recommended for patients with end-stage renal disease.


National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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