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Usual Dosing (Adults)

Usual starting dose: 500mg po bid or 850 mg po qd. Dosage increases should be made in increments of 500 mg weekly or 850 mg q2 weeks, up to a total of 2000 mg per day, given in divided doses. (Maximum: 2550mg/day).

Glucophage XR: Starting dose: 500 mg qd with the evening meal. Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg daily with the evening meal.

Renal Dosing

dialysis Contraindicated: Males with a serum creatinine > 1.5 mg/dl or females >1.4 mg/dl.

Also patients with an abnormal creatinine clearance (~ <60-70 ml/min).


dialysis Metformin use is contraindicated.


National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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