Metformin

Usual Dosing (Adults)

Usual starting dose: 500mg po bid or 850 mg po qd. Dosage increases should be made in increments of 500 mg weekly or 850 mg q2 weeks, up to a total of 2000 mg per day, given in divided doses. (Maximum: 2550mg/day).

Glucophage XR: Starting dose: 500 mg qd with the evening meal. Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg daily with the evening meal.

Renal Dosing

Contraindicated: Males with a serum creatinine > 1.5 mg/dl or females >1.4 mg/dl.

Also patients with an abnormal creatinine clearance (~ <60-70 ml/min).

Hemodialysis

Metformin use is contraindicated.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates. A local search option of this data can be found here.