Entecavir

Usual Dosing (Adults)

INDICATIONS AND USAGE
BARACLUDE is a nucleoside analogue indicated for the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

DOSAGE AND ADMINISTRATION
Nucleoside-treatment-naïve with compensated liver disease (≥16 years old): 0.5 mg once daily.
Lamivudine-refractory or known lamivudine or telbivudine resistance mutations (≥16 years old): 1 mg once daily.

Decompensated liver disease (adults): 1 mg once daily.

Renal impairment: Dosage adjustment is recommended if creatinine clearance is less than 50 mL/min.

BARACLUDE should be administered on an empty stomach.

Renal Dosing

[CRCL > 50 ml/min]: No changes

[30-49 ml/min]: Administer 50% of usual dose

[10-29 ml/min]: Administer 30% of usual dose

[<10 ml/min]: (including dialysis): Administer 10% of usual dose; administer after hemodialysis

Hemodialysis

Administer 10% of usual dose (administer after hemodialysis)

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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