Enoxaparin

Usual Dosing (Adults)

DVT prophylaxis (hip / knee surgery): 30 mg SC every 12 hours starting 12-24 hours postop. Alternative for hip: 40 mg SC once daily starting 12 hours preop.

DVT treatment (Outpatient): 1 mg/kg SC every 12 hours until oral anticoagulation established.

DVT treatment (Inpatient): 1 mg/kg SC every 12 hours or 1.5 mg/kg SC once daily.

Unstable angina or non-Q-wave MI: 1 mg/kg SC every 12 hours

Prophylaxis in acute medically ill patients (high risk): 40 mg SC qd x 6-11 days (up to 14 days).

Renal Dosing

[CRCL >30 ml/min]: No specific adjustment recommended (per manufacturer).

[CRCL < 30 ml/min]:
DVT prophylaxis in abdominal surgery, hip replacement, knee replacement, or in medical patients during acute illness:
30mg SC qd.

DVT treatment (inpatient or outpt treatment in conjunction with warfarin): 1 mg/kg SC q24h.

Unstable angina, non-Q-wave MI (with ASA): 1 mg/kg SC q24h.

Hemodialysis

Enoxaparin has not been FDA approved for use in dialysis patients. It's elimination is primarily via the renal route. Serious bleeding complications have been reported with use in patients who are dialysis dependent or have severe renal failure.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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