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Usual Dosing (Adults)

Treatment: 800mg qhs, or 300mg PO/IV q6h, or 400mg q12h.
Maintenance: 400 mg qhs.
Esophagitis/reflux: 800mg bid or 400mg po q6h.
Maximum dose/day: 2400 mg.

Renal Dosing

dialysis [>50 ml/min]: No changes.
[10-50]: Give 75% of usual dose at usual interval.
[<10 ml/min]: Give 50% of usual dose at usual interval.

[>30 ml/min]: no change
[15-30]: usual dose q8h
[<15]: usual dose q12h
[>50 ml/min]: 300mg q6h
[30-50]: 300mg q8h
[10-29]: 300mg q12h
[<10]: 300mg q24h


dialysis [<10]: Give 50% of usual dose at usual interval. Some sources recommend giving 300mg 24h.  Doses should be scheduled after dialysis on dialysis days.


National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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