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Usual Dosing (Adults)

1-2 grams IV/IM q8-12 hours. 
[Life-threatening]: 3-4 gm IV q8h or 2 gm q4h.

(Maximum 12g /day).

Renal Dosing

dialysis [CRCL >79 ]: no changes

[50-79 ]: 500 mg to 1.5 gm q8h

[5-49 ]: 250mg – 1 gm q12h

[0-4 – dialysis pt]: 250-500 mg q24h or 500mg to 1 gm q48h.


dialysis Hemodialysis: 
250-500 mg q24h or 500mg to 1 gram q48h (dosages should be timed after hemodialysis on dialysis days.)

PD: 500mg – 1 gram q24h.


National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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