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Usual Dosing (Adults)

[Uncomplicated]: 1 gm q6-8h. 
[Moderate to severe]: 1 gram q4h or 2 gm q6-8h. 
[Life-threatening]: 2 gm q4h or 3 gm q6h.

Renal Dosing

dialysis [CRCL >50 ml/min]: No changes

[30-50 ]: 1-2 grams q8-12 hours. 

[10-29 ]: 1-2 grams q12-24 hours. 

[5-9 ]: 0.5 - 1 gm q12-24h. 

[<5 ml/min]: 0.5 to 1 gram q24-48h. 


dialysis Hemodialysis: 
500mg to 1 gram q24-48h. Also, give a supplemental dose after each dialysis (usual dose: 1 gram).

PD: 1 gram q24h


National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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