Cefazolin

Usual Dosing (Adults)

[Usual]: 500mg to 1g IV q8h.
[Moderate to severe]: 500mg – 1 gram q6-8h.
[life-threatening]: 1–1.5g q6h.
[Maximum dosage/day]: 12 grams.

DOSAGE AND ADMINISTRATION
Usual Adult Dosage

Type of Infection	Dose	Frequency
Moderate to severe infections	500 mg to 1 gram	every 6 to 8 hrs.
Mild infections caused by susceptible gram-positive cocci	250 mg to 500 mg	every 8 hours
Acute, uncomplicated urinary tract infections	1 gram	every 12 hours
Pneumococcal pneumonia	500 mg	every 12 hours
Severe, life-threatening infections (e.g., endocarditis, septicemia)*	1 gram to 1.5 grams	every 6 hours

*In rare instances, doses of up to 12 grams of ANCEF per day have been used.

Renal Dosing

[CRCL >55 ml/min]: no change.

[35-54 ml/min]: Maximum interval: q8h. 500mg – 1.5g q8h.

[11-34 ml/min]: 500mg – 1.5g x 1, then 0.5 - 1 gram q12h.

[<10 ml/min]: 500 mg - 1 gram q18-24h.

Dosage Adjustment for Patients With Reduced Renal Function
ANCEF may be used in patients with reduced renal function with the following dosage adjustments: Patients with a creatinine clearance of 55 mL/min. or greater or a serum creatinine of 1.5 mg % or less can be given full doses. Patients with creatinine clearance rates of 35 to 54 mL/min. or serum creatinine of 1.6 to 3.0 mg % can also be given full doses but dosage should be restricted to at least 8 hour intervals. Patients with creatinine clearance rates of 11 to 34 mL/min. or serum creatinine of 3.1 to 4.5 mg % should be given 1/2 the usual dose every 12 hours. Patients with creatinine clearance rates of 10 mL/min. or less or serum creatinine of 4.6 mg % or greater should be given 1/2 the usual dose every 18 to 24 hours. All reduced dosage recommendations apply after an initial loading dose appropriate to the severity of the infection.

Hemodialysis

500 mg – 1 gram IV q24h. (Give dose post-dialysis on dialysis days.)

PD: 500 mg q12h.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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