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MedlinePlus is a service of the National Library of Medicine (NLM), the world's largest medical library, which is part of the National Institutes of Health (NIH). It was built as an online health information resource for patients and their families and friends.

MedlinePlus presents high-quality, easy to understand, relevant health and wellness information that is trusted.

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MedlinePlus at a Glance

  • Offers information on health topics, human genetics, medical tests, medications, dietary supplements, and healthy recipes.
  • Sourced from more than 1,600 selected organizations.
  • Provides 40,000 links to authoritative health information in English and 18,000 links to information in Spanish.
  • In 2018, 277 million users viewed MedlinePlus more than 700 million times.

Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse.

Symptoms in the affected area are:

  • Dramatic changes in skin temperature, color, or texture
  • Intense burning pain
  • Extreme skin sensitivity
  • Swelling and stiffness in affected joints
  • Decreased ability to move the affected body part

The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms.

There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally the symptoms go away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks.

NIH: National Institute of Neurological Disorders and Stroke




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