Multiple Sclerosis Prognostic Elements
Multiple sclerosis (MS) is the most prevalent chronic inflammatory disease of the central nervous system. This incurable disease affects more than 2 million people worldwide with about 75% of cases occurring in women.
MS is a demyelinating disease characterized by multifocal and temporally scattered central nervous system (CNS) damage which leads to the axonal damage. Exogenous, environmental, and genetic factors contribute to the development of MS and the correlations of these factors are still being widely studied. Depending on the severity of signs and symptoms, MS can be described as benign or malignant.
MS progression is highly variable from one person to the next and its not correlated to risk factors. No treatment currently available completely halts its progression. Many patients have symptoms that persist with periods of remission that vary greatly in duration. After ten to twenty years, many MS patients develop progressive symptoms and impairments.
Common Initial Symptoms
- Blurry vision
- Loss of bladder control.
- Impaired ambulation.
- Slowed mental abilities
Using this program
Select any of the following features
that are present in the patient to determine their
prognostic value in predicting a diagnosis of multiple sclerosis.
e.g. frequency and/or urgency of urination
Cortical deficits such as aphasia, apraxia, alexia, or neglect
Deficit developing within minutes
Diplopia (double vision)
Heat sensitivity (Uhthoff phenomenon)
Lhermitte sign (electric shock-like sensations upon flexion of the neck)
Limb ataxia - incoordination of limb movement
/ subacute)- muscle weakness, impaired balance, and spasticity
Onset between ages 15 and 50 years
Onset before age 10 or after age 50 years
Relapses and remissions
Rigidity or sustained dystonia
Sensory in face e.g.stabbing pain
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