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Pharmacokinetics for pediatrics (dosing by levels full version)

Co-developed with Clinical Pharmacy Staff, Dayton Children’s Hospital, One Children’s Plaza
Patient:     Location:

Gender:      Drug:

Peak level obtained:  mcg/mL   Number hours post dose

Trough level obtained: mcg/mL  Number hours post dose:

Current dose being given mg    Current dosing interval:

Current infusion time (hrs):

(Note: program adds 0.5 hours to infusion time to account for a longer distribution phase in neonates)

Desired peak:   mcg/ml     Desired trough:    mcg/mL

Sample problem to aid filling out the table above

Patient is receiving Gentamicin 120mg IVPB q8h. Infusion time is 30 minutes. A peak is drawn 1 hour after the
start of the infusion and a trough is drawn 5 hours after the start of the infusion (note the entries below). The program will take into account the infusion time when calculating the actual peak (do not subtract the infusion time from the number of hours post dose). This program assumes that information provided is based on steady state. If you were to calculate these values by hand, the actual Cmax would occur at the end of the infusion. In this example (t)=  1- 0.5 = 0.5. The Cmin calculation would use a time value of (8 - 5 = 3 hours).
Pharmacokinetics for pediatrics – dosing by levels full version