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Corticosteroid -Glucocorticoid Conversion based on potency

Corticosteroid converter


The potency and duration of action of the various glucocorticoids can vary greatly. Oral potency may be less than parenteral potency because significant amounts (up to 50% in some cases) may not reach the circulation. Cortisol is the standard of comparison for glucocorticoid potency.


Dose (mg): 

Conversion Data
Glucocorticoid Approximate Equivalent dose (mg) Half-life (Biologic) hours
Short-Acting
Cortisone    25 8-12
Hydrocortisone    20 8-12
Intermediate-Acting
Methylprednisolone 4 18-36
Prednisolone 5 18-36
Prednisone 5 18-36
Triamcinolone 4 18-36
Long-Acting
Betamethasone 0.6 - 0.75 36-54
Dexamethasone 0.75 36-54

References: 
Dixon JS. Second-line Agents in the Treatment of Rheumatic Diseases. Informa Health Care, 1991. (456).

Meikle AW and Tyler FH. Potency and duration of action of glucocorticoids. Am J of Med 1977;63;200.

Webb R, Singer M. Oxford Handbook of Critical Care. Oxford ; New York : Oxford University Press, 2005.
Corticosteroid -Glucocorticoid Conversion based on potency

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