Pharmacokinetic Dosing Calculator (2019)
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This latest version is based on a comprehensive review of the most recent
pharmacokinetic textbooks. Some of the sources used are listed
here.
Link to the standalone Vancomycin AUC related dosing
Calculator >>
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Patient-Specific Data
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Patient:
Location:
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Age:
Sex: Serum Creatinine:
Height:
Weight:
Clearance
method:
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Drug Selection, Levels, and Drug-specific PK Parameters:
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Select Drug:
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Desired Peak:
mcg/ml
Desired Trough:
mcg/ml |
Volume of distribution:
L/kg
Usual range: aminoglycosides: 0.25 - 0.35.
Vanco: 0.65 - 0.9
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Infusion time (ti):
Additional Info
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Select elimination rate constant (Ke) calculation method:
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Background information
(VANCOMYCIN):
Ke =
0.00083 x CRCL + 0.0044 Usual Vd reported: 0.9 L/kg. (0.7
- 0.9 L/kg) Ref: 3,4,5
Clearance method: CL
(L/hr) = CrCl (ml/min) x 0.06. Ke = Vanco CL/Vd. Usual Vd:
0.7L/kg. Ref: 6
Ke (hr-1) =
[(0.695[(CrCl mL/min)/TBW kg] + 0.05) x 0.06] / Vd factor ]
Usual Vd: 0.7L/kg. Ref: 2
New option based on input from clinicians - general assumption,
adjusted body weight may be used in the morbidly obese patients
receiving vancomycin: Historically actual or total
is used in all cases.
Use
Adjusted body weight or
Use Actual
(total) weight for vanco dosing.
(Aminoglycosides):
Clearance method: CL
(L/hr) = CrCl (ml/min) x 0.06. Ke = CL/Vd. Ref: 5,6
Ke
= 0.00293(CrCl) + 0.014 Ref: 1,4
Ke (hr-1) = (0.0024 x CrCl) + 0.01 Ref: 5
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Amputations (Optional Field)
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Loading Dose - Aminoglycosides
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(optional)
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(optional) |
Process form entries
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Cockcroft and Gault equation utilizing the ibw (Ideal body weight) to
calculate an estimated creatinine clearance
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Cockcroft and Gault equation:
CrCl = [(140 - age) x IBW] / (Scr x 72) (x 0.85 for females)
Note: if the ABW (actual body weight) is less than the IBW use the
actual body weight for calculating the CRCL.
Estimate Ideal body weight in (kg)
Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet. |
Salazar-Corcoran Equation
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Estimating Creatinine Clearance (ml/min) -
Units: Weight: kg Height: meters.
For Men:
[137 - age] x [(0.285 x weight(kg)) + (12.1 x height(m)2)] /
(51 x SCr)
For Women:
[146 - age] x [(0.287 x weight(kg)) + (9.74 x height(m)2)] /
(60 x SCr)
Salazar DE, Corcoran GB: Predicting creatinine clearance and renal drug
clearance in obese patients from estimated fat-free body mass. Am J Med 84:
1053–1060, 1988. |
References
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Bauer LA. The Aminoglycoside Antibiotics. In Bauer LA, ed. Applied
Clinical Pharmacokinetics. 2nd ed. New York, NY: McGraw Hill Medical;
2008:97-206.
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Bauer LA. Vancomycin. In Bauer LA, ed. Applied Clinical
Pharmacokinetics. 2nd ed. New York, NY: McGraw Hill Medical; 2008:207-298.
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Burton ME, Shaw LM, Schentag JJ, Evans WE. Applied Pharmacokinetics &
Pharmacodynamics: Principles of Therapeutic Drug Monitoring. 4th ed.
Philadelphia: Lippincott Williams & Wilkins; 2006.
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DiPiro JT, Spruill WJ, Wade WE, Blouin RA, Pruemer JM. Concepts in Clinical
Pharmacokinetics, (5th Edition) 2010. American Society of Health Systems
Pharmacist, Bethesda, MD.
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Murphy JE. Aminoglycosides. In: Murphy JE, ed. Clinical Pharmacokinetics, 4th
ed. Bethesda, MD: American Society of Health-System Pharmacists, 2008:27-60.
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Winter ME. Basic clinical pharmacokinetics. 5th ed. Baltimore: Lippincott
Williams and Wilkins; 2010.
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Winter MA, Guhr KN, Berg GM. Impact of various body weights and
serum creatinine concentrations on the bias and accuracy of the
Cockcroft-Gault equation. Pharmacotherapy 2012; 32: 604-612 [PMID:
22576791 DOI: 10.1002/j.1875-9114.2012.01098.x]
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