(1) Segs and bands reported as a percentage:
WBC * ((segs / 100) + (bands / 100))(2) Segs and bands reported in total numbers:
WBC * (segs + bands)
Neutrophils (aka polymorphonuclear cells, PMNs, granulocytes, segmented neutrophils, or segs) fight against infection and represent a subset of the white blood count. Neutropenia by definition is an ANC below 1800/mm3 (some sources use a lower value).
Absolute neutrophil count (ANC) of 1000-1800:
Most patients will be given chemotherapy in this range.
Risk of infection is considered low.
Mild neutropenia – Absolute neutrophil count (ANC) of 500-1000:
Carries with it a moderate risk of infection.
Absolute neutrophil count (ANC) of less than 500:
Severe neutropenia – high risk of infection. Remember that a reduced WBC is known as leukopenia.
The WBC consists of the following (differential):
Monocytes: 2-9% (average: 4%).
ANC = Total WBC x (% “Segs” + % “Bands”)
Equivalent to: WBC x ((Segs/100) + (Bands/100))
The ANC refers to the total number of neutrophil granulocytes present in the blood.
Normal value: ≥ 1500 cells/mm3.
Mild neutropenia: ≥1000 – <1500/mm3.
Moderate neutropenia: ≥500 – <1000/mm3.
Severe neutropenia: < 500/mm3.
Ayalew Tefferi, MD, ed. Primary Hematology. Totowa, NJ: Humana Press, 2001