Navigation (cephalosporins) |
|
Infectious Disease -ALL Agents (INDEX)
|
| First Generation | ||
| Cefadroxil Duricef ® TOP
|
Dosing (Adults): 1-2 grams per day divided qd or q12h.
Renal Dosing: [CRCL >50 ]: No change. [25-50 ]: 1 gram x 1, then 500mg q12h. [10-25 ]: 1 gram po x 1, then 500mg q24h. [<10 ]: 1 gram x 1, then 500 mg q36h. Hemodialysis: 1 gram x 1, then 500 mg q36h. Dose should be given after dialysis on dialysis days. Alternatively, give 1 gram after each hemodialysis session plus an additional 1 gram dose q72h. |
|
| Cefazolin Ancef ®TOP |
[Dosing -Usual]: 500mg to 1g IV q8h. [Moderate to severe]: 500mg – 1 gram q6-8h. [life-threatening]: 1–2 grams q6h. [Maximum dosage/day]: 12 grams.Renal dosing: [CRCL >55 ml/min]: no change. [35-54 ml/min]: Maximum interval: q8h. 500mg – 1.5g q8h. [11-34 ml/min]: 500mg – 1.5g x 1, then 0.5 - 1 gram q12h. [<10 ml/min]: 500 mg - 1 gram q18-24h. Hemodialysis: 500 mg – 1 gram IV q24h. (Give dose post-dialysis on dialysis days.) PD: 500 mg q12h. |
|
| Cephradine Velosef ® TOP
|
Dosing (Adults): 250-500 mg every 6-12 hours Renal Dosing: [CRCL 10-50 ml/min]: Administer 50% of dose. [<10 ml/min]: Administer 25% of dose. |
|
| Cephalexin Keflex ® TOP
|
Dosing (usual): 250 – 500mg po q6h. [Severe infections]: 1 gm q6h. (Maximum: 4 g/day). Other: Streptococcal pharyngitis, skin and skin structure infections: 500 mg orally q12h. Uncomplicated cystitis: 500 mg orally q12h.Renal Dosing: [CRCL >30 ]: no changes. [10-30 ]: 250-500 mg q8-12h. [<10 ]: 250-500mg q12-24h. Hemodialysis: 250-500mg q12-24h (Dose should be given after dialysis on dialysis days). |
|
| Second Generation | ||
| Cefaclor Ceclor ®TOP
|
Dosing (Adults): 250–500 mg orally every 8 hours or if the extended release form is used: 375–500 mg every 12 hours.
Renal dosing: [CRCL >10 ]: no change. [<10 ]: Give 50% of usual dose at same interval. Hemodialysis: 250mg q8-12 hours. Make sure dose is given after dialysis. |
|
| Cefotetan TOP | Dosing (Adults): 1-2 grams q12h. [Life-threatening]: 3 grams IV q12h. Renal Dosing: [CRCL >30 ml/min]: No changes. [10-30 ]: 1-2g q24h or 500mg-1g q12h. [<10 ]: 1-2 grams q48h or 250-500mg q12h. Hemodialysis: 250 - 500 mg q24h on non-HD days and 500 mg - 1 gm q24h on HD days. PD: 1 gram q24h |
|
| Cefoxitin Mefoxin ®TOP |
Dosing (Adults): [Uncomplicated]: 1 gm q6-8h. [Moderate to severe]: 1 gram q4h or 2 gm q6-8h. [Life-threatening]: 2 gm q4h or 3 gm q6h. Renal Dosing: [CRCL >50 ml/min]: No changes. [30-50 ]: 1-2 grams q8-12 hours. [10-29 ]: 1-2 grams q12-24 hours. [5-9 ]: 0.5 - 1 gm q12-24h. [<5 ]: 0.5 to 1 gram q24-48h. Hemodialysis: 500mg to 1 gram q24-48h. Also, give a supplemental dose after each dialysis (usual dose: 1 gram). PD: 1 gram q24h |
|
| Cefprozil Cefzil ®TOP
|
Dosing (Adults): 250 – 500 mg po q12h. Specific guidelines: Pharyngitis/tonsillitis: 500 mg orally every 24 hours x 10 days. Secondary or acute exacerbation of chronic bronchitis: 500 mg orally every 12 hours x 10 days.Renal Dosing: [CRCL >30 ]: No changes. [<29 ]: 50% of usual dosage q12-24h. Hemodialysis: 50% of usual dosage q12-24h. (Administer after the completion of hemodialysis on dialysis days). |
|
| Cefuroxime Zinacef ®TOP |
Dosing (Adults): 750 mg to 1.5 gm IV q8h.
Renal Dosing: |
|
| Cefuroxime axetil Ceftin ® TOP
|
Dosing (Adults): 250 – 500mg orally q12h.
Renal Dosing: |
|
| loracarbef Lorabid ® TOP
|
Dosing (Adults): Skin and soft tissue infections: 200 mg orally every 12 hours x 7 days. Uncomplicated urinary tract infections: 200 mg once daily for 7 days. Uncomplicated pyelonephritis: 400 mg orally every 12 hours for 14 days. Pharyngitis/tonsillitis: 200 mg orally every 12 hours for 10 days. Sinusitis: 400 mg orally every 12 hours for 10 days. Upper/lower respiratory tract infection: 400 mg orally every 12 hours for 7-14 days.Renal Dosing: [CRCL >50 ml/min]: no changes. [CRCL 10-49 ml/min]: Administer 50% of usual dose at usual interval or usual dose given half as often. [CRCL <10 mL/min]: Administer usual dose every 3-5 days. [Hemodialysis]: Doses should be administered after dialysis sessions.Supplied: 200 mg, 400 mg capsule. Powder for oral suspension: 100 mg/5 ml (100 ml); 200 mg/5 ml (100 ml). |
|
| Third Generation | ||
| Cefdinir: Omnicef ®TOP
|
Dosing (Adults): 1) Acute exacerbations of chronic bronchitis, pharyngitis , tonsillitis: 300 mg orally twice daily for 5-10 days or 600 mg once daily for 10 days. 2) Community-acquired pneumonia, uncomplicated skin and skin structure infections: 300 mg orally twice daily for 10 days. 3) Acute maxillary sinusitis: 300 mg orally twice daily or 600 mg once daily for 10 days
Renal Dosing: [CRCL >30 ml/min]: no change. [<30 ]: 300 mg q24h. Hemodialysis: Give 300mg qod. On dialysis days, give 300mg after dialysis. |
|
| Cefixime Suprax®TOP
|
Dosing (Adults): 400 mg orally once daily or 200mg twice daily. Uncomplicated cervical/urethral gonorrhea due to N. gonorrhoeae:400 mg orally x 1. Renal Dosing: [CRCL >60 ml/min]: no change. [21-60]: Administer 75% of the standard dose. [<20 ml/min]: Administer 50% of the standard dose. |
|
| Cefoperazone Cefobid ®TOP |
Dosing (Adults): 1-2 grams q8-12 hours. Renal dosing: no changes needed. Hemodialysis: No changes needed. (Ideally, dosage should be scheduled following a dialysis period). |
|
| Cefotaxime Claforan ®TOP |
Dosing (Adults): [Uncomplicated]: 1 gram IV/IM q12h. [Moderate to severe]: 1-2 grams IV/IM q8h. [Severe]: 2 grams IV q6-8h. [Life-threatening]: 2 grams IV q4hRenal Dosing: [CRCL >50 ml/min]: no change. [10-50 ]: 1-2 grams q8-12h. [<10 ] : 1-2 grams q24h. Hemodialysis: 500mg to 2 grams q24h, plus give a supplemental dose post-dialysis. PD: 1 gram q24h |
|
| Cefpodoxime Vantin ® TOP
|
Dosing (Adults): 100 to 400 mg orally every 12h hours.
-Acute community-acquired pneumonia and bacterial exacerbations of chronic bronchitis: 200 mg orally every 12 hours x 10-14 days. -Acute maxillary sinusitis: 200 mg orally every 12 hours x 10 days. -Skin / skin structure: Oral: 400 mg every 12 hours x 7-14 days. UTI: 100 mg orally every 12 hours x 7 days. Renal Dosing: |
|
| Ceftazidime Fortaz ®TOP |
Dosing (usual): 1 gram IV q8-12 hours. [Severe / Life-threatening]: 2 grams q8 hours. (Max 6 grams/day).Bone and joint infections: 2 grams IV q12h. Intra-abdominal or gynecologic infection: 2 g IV q8h. Meningitis: 2 g IV q8h. Skin and soft tissue infections: 0.5 to 1 g IV q8h. UTI: 250-500mg IV q8-12 hoursRenal Dosing: [CRCL >50 ]: No changes. [31-50 ]: 1 gram q12h. [16-30 ]: 1 gram q24h. [6-15 ]: 500 mg q24h. [<5 –dialysis]: 500 mg q48h. Note: all dosages listed for renal insufficiency may be increased by 50% in severe infections. Hemodialysis: Loading dose: 1 gram x 1, then 1 gram after each hemodialysis session. [Alternatively]: Give 1 gram q48h, plus give an additional 1 gram dose after each dialysis session. CAPD: 1 gram x 1, followed by 500mg q24h. |
|
| Ceftibuten Cedax ®TOP
|
Dosing (Adults): 400 mg orally q24h.
Renal Dosing: |
|
| Ceftizoxime Cefizox ®TOP |
Dosing (Adults): 1-2 grams IV/IM q8-12 hours. [Life-threatening]: 3-4 gm IV q8h or 2 gm q4h. Renal Dosing: [CRCL >79 ]: no changes. [50-79 ]: 500 mg to 1.5 gm q8h. [5-49 ]: 250mg – 1 gm q12h. [0-4 – dialysis pt]: 250-500 mg q24h or 500mg to 1 gm q48h. Hemodialysis: 250-500 mg q24h or 500mg to 1 gram q48h (dosages should be timed after hemodialysis on dialysis days.) PD: 500mg – 1 gram q24h. |
|
| Ceftriaxone Rocephin ®TOP |
Dosing (Adults): 1-2 grams q12-24h. [Meningitis]: Give 100 mg/kg/day (not to exceed 4 grams) qd or in divided doses q12h. Other: Gonococcal infection (uncomplicated): 125-250 mg IM x 1. PID: 250 mg IM x 1.Renal Dosing: No adjustments are necessary, however, blood levels are recommended in dialysis patients. Adults with both renal and hepatic failure should not receive more than 2 gm/day. Hemodialysis: No specific recommendations per manufacturer except that blood levels are recommended in dialysis patients. The dosage should not exceed 2 grams per day. Some studies have recommended giving cefriaxone 1 gram q48h making sure the dose is given after hemodialysis on dialysis days. PD: 750mg q12h. |
|
| Fourth Generation | ||
| Cefepime Maxipime ®TOP |
Dosing (Adults): [Mild to moderate]: 500 mg to 1 gram IV q12h. [Moderate to severe]: 1-2 grams IV q12h. [Febrile neutropenic patients]: 2 grams IV q8h.Renal Dosing: [CRCL >60 ml/min]: no change. [30-60 ]: 500mg to 2 grams q24h. Neutropenic: 2 grams q12h. [11-29 ]: 500 mg to 1 gram q24h. Neutropenic: 2 grams q24h. [<11 ]: 250 – 500 mg q24h. Neutropenic: 1 gram q24h. Hemodialysis: 250 – 500 mg q24h. Neutropenic: 1 gram q24h. // Give additional dose post dialysis. PD: 1-2 grams q48h |
|
| Fifth Generation | ||
| TEFLARO™ (ceftaroline fosamil) | See local monograph | |
