| CLINICAL PHARMACOLOGY
Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects. The mechanism of action of pentosan polysulfate sodium in interstitial cystitis is not known.
INDICATIONS AND USAGE
Adults: Oral: 100 mg 3 times/day taken with water 1 hour before or 2 hours after meals
| Drug Category: Cholinergic Agonist. Indication: Nonobstructive urinary retention and retention due to neurogenic bladder.
Gastroesophageal reflux (unlabeled): Oral: 25 mg 4 times/day.
Supplied: [Tablet: 5 mg, 10 mg, 25 mg, 50 mg]
| Alum irrigation -BLADDER HEMORRHAGE
An astringent that induces hemostasis by precipitating protein over the bleeding surface. Since it has low cell permeability, its action is limited to the cell surface and interstitial spaces.
Usual concentration: 1 percent alum bladder irrigation (base solution usually saline or sterile water). Reserved for moderate to severe hematuria/bladder hemorrhage. Average instillation rate: 250-300 ml/hour (2.5 – 3 grams/hour). In mild cases, saline continuous bladder irrigation or suprahydration may be used.
National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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