Drug Comparisons
Statins (HMG-CoA Reductase Inhibitors) |
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| ' -- ' Signifies that equivalent tablet size is not available (comparable dose is either too high or too low) | |||||||||||
| Drug Comparisons - Home Page | |||||||||||
Equivalent Dosages -1 |
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| Atorvastatin (Lipitor ®): -- (see tablet strengths) |
Fluvastatin (Lescol ®): 20 mg |
Lovastatin (Mevacor ®): 10 mg |
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| Pravastatin (Pravachol ®): 10 mg |
Rosuvastatin (Crestor ®): -- |
Simvastatin (Zocor ®): 5 mg |
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Equivalent Dosages - 2 |
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| Atorvastatin (Lipitor ®): -- |
Fluvastatin (Lescol ®): 40 mg |
Lovastatin (Mevacor ®): 20 mg |
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| Pravastatin (Pravachol ®): 20 mg |
Rosuvastatin (Crestor ®): -- |
Simvastatin (Zocor ®): 10 mg |
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Equivalent Dosages - 3 |
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| Atorvastatin (Lipitor ®): 10 mg |
Fluvastatin (Lescol ®): 80 mg |
Lovastatin (Mevacor ®): 40 mg |
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| Pravastatin (Pravachol ®): 40 mg |
Rosuvastatin (Crestor ®): 5 mg |
Simvastatin (Zocor ®): 20 mg |
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Equivalent Dosages - 4 |
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| Atorvastatin (Lipitor ®): 20 mg |
Fluvastatin (Lescol ®): -- |
Lovastatin (Mevacor ®): 80 mg |
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| Pravastatin (Pravachol ®): 80 mg |
Rosuvastatin (Crestor ®): 5 - 10 mg |
Simvastatin (Zocor ®): 40 mg |
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Equivalent Dosages - 5 |
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| Atorvastatin (Lipitor ®): 40 mg |
Fluvastatin (Lescol ®): -- |
Lovastatin (Mevacor ®): -- |
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| Pravastatin (Pravachol ®): -- |
Rosuvastatin (Crestor ®): 10 - 20 mg |
Simvastatin (Zocor ®): 80 mg |
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Atorvastatin (Lipitor ®) |
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| Supplied: 10 mg, 20 mg, 40 mg, 80 mg Dosing: Hyperlipidemias: Adults: Oral: Initial: 10-20 mg once daily. Patients requiring >45% reduction in LDL-C may be started at 40 mg once daily. Range: 10 to 80 mg once daily. Adjustments should be made at intervals of 2-4 weeks. |
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Fluvastatin (Lescol ®) |
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| Supplied: Capsule: 20 mg, 40 mg. Tablet, extended release (Lescol® XL): 80 mg Dosing: Dyslipidemia: Oral: (Adults): Patients requiring >/= 25% decrease in LDL-C: 40 mg capsule once daily in the evening, 80 mg XL tablet once daily (anytime), or 40 mg capsule twice daily. Patients requiring <25% decrease in LDL-C: Initial: 20 mg capsule once daily in the evening; may increase based on tolerability and response to a maximum recommended dose of 80 mg/day, given in 2 divided doses (capsule) or as a single daily dose (XL tablet). |
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Lovastatin (Mevacor ®) |
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| Supplied: Tablet: 10 mg, 20 mg, 40 mg. Tablet, extended release: 20 mg, 40 mg, 60 mg Dosing: Dyslipidemia: Oral: (Adults): Initial: 20 mg with evening meal, then adjust at 4-week intervals; maximum: 80 mg/day immediate release tablet or 60 mg/day extended release tablet.Dosage modification/limits based on concurrent therapy: Cyclosporine and other immunosuppressant drugs: Initial dose: 10 mg/day with a maximum recommended dose of 20 mg/day. Concurrent therapy with fibrates, danazol, and/or lipid-lowering doses of niacin (>1 g/day): Maximum recommended dose: 20 mg/day. Concurrent use with fibrates should be avoided unless risk to benefit favors use. Concurrent therapy with amiodarone or verapamil: Maximum recommended dose: 40 mg/day of regular release or 20 mg/day with extended release. |
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Pravastatin (Pravachol ®) |
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| Supplied: 10 mg, 20 mg, 40 mg, 80 mg Dosing: Hyperlipidemias: Oral: (Adults): Initial: 40 mg once daily; titrate dosage to response (usual range: 10-80 mg) (maximum dose: 80 mg once daily).Dosage adjustment based on concomitant cyclosporine: Oral: Initial: 10 mg/day, titrate with caution (maximum dose: 20 mg/day). |
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Rosuvastatin (Crestor ®) |
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| Supplied: 5 mg, 10 mg, 20 mg, 40 mg Dosing: Hypercholesterolemia; mixed dyslipidemia: Oral: (Adults): Initial dose: 10 mg once daily (20 mg in patients with severe hypercholesterolemia). Conservative dosing: Patients requiring less aggressive treatment or predisposed to myopathy (including patients of Asian descent): 5 mg once daily. Titration: After 2 weeks, may be increased by 5-10 mg once daily; dosing range: 5 to 40 mg/day (maximum dose: 40 mg once daily). Dosage adjustment with concomitant medications: Oral: Cyclosporine: Rosuvastatin dose should not exceed 5 mg/day. Gemfibrozil: Rosuvastatin dose should not exceed 10 mg/day. Dosage adjustment for persistent, unexplained proteinuria while on 40 mg/day: Reduce dose and evaluate causes. |
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Simvastatin (Zocor ®) |
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| Supplied: 5 mg, 10 mg, 20 mg, 40 mg, 80 mg Dosing: Oral: (Adults): Prevention of cardiovascular events, hyperlipidemias: Oral: 20-40 mg once daily in the evening; range: 5 to 80 mg/day. Homozygous familial hypercholesterolemia: Oral: 40 mg once daily in the evening or 80 mg/day (given as 20 mg, 20 mg, and 40 mg evening dose). Patients requiring only moderate reduction of LDL-cholesterol: May be started at 10 mg once daily Patients requiring reduction of >45% in low-density lipoprotein (LDL) cholesterol: May be started at 40 mg once daily in the evening. Patients with CHD or at high risk for CHD: Dosing should be started at 40 mg once daily in the evening; simvastatin may be started simultaneously with diet.Dosage adjustment for simvastatin with concomitant medications: Cyclosporine or danazol: Patient must first demonstrate tolerance to simvastatin >/= 5 mg once daily: Initial: 5 mg, should not exceed 10 mg/day. Fibrates or niacin: Dose should not exceed 10 mg/day. Amiodarone or verapamil: Dose should not exceed 20 mg/day. |
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