Enalaprilat - Vasotec ®
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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
|[0 - 2.5 mg] [50 ml] [15-20 minutes]|
Stability / Miscellaneous
EXP: 1 DAY (RT).
May also be given IV push over 5 minutes.
Ace inhibitor conversion:
DOSAGE AND ADMINISTRATION
The dose in hypertension is 1.25 mg every six hours administered intravenously over a five minute period. A clinical response is usually seen within 15 minutes. Peak effects after the first dose may not occur for up to four hours after dosing. The peak effects of the second and subsequent doses may exceed those of the first.
No dosage regimen for enalaprilat injection has been clearly demonstrated to be more effective in treating hypertension than 1.25 mg every six hours. However, in controlled clinical studies in hypertension, doses as high as 5 mg every six hours were well tolerated for up to 36 hours. There has been inadequate experience with doses greater than 20 mg per day.
In studies of patients with hypertension, enalaprilat injection has not been administered for periods longer than 48 hours. In other studies, patients have received enalaprilat injection for as long as seven days.
The dose for patients being converted to enalaprilat injection from oral therapy for hypertension with enalapril maleate is 1.25 mg every six hours. For conversion from intravenous to oral therapy, the recommended initial dose of Enalapril Maleate Tablets is 5 mg once a day with subsequent dosage adjustments as necessary.
Patients on Diuretic Therapy
For conversion from intravenous to oral therapy, the recommended initial dose of Enalapril Maleate Tablets for patients who have responded to 0.625 mg of enalaprilat every six hours is 2.5 mg once a day with subsequent dosage adjustment as necessary.
Dosage Adjustment in Renal Impairment
If after one hour there is an inadequate clinical response, the 0.625 mg dose may be repeated. Additional doses of 1.25 mg may be administered at six hour intervals.
For dialysis patients, see below, Patients at Risk of Excessive Hypotension.
For conversion from intravenous to oral therapy, the recommended initial dose of Enalapril Maleate Tablets is 5 mg once a day for patients with creatinine clearance >30 mL/min and 2.5 mg once daily for patients with creatinine clearance ≤30 mL/min. Dosage should then be adjusted according to blood pressure response.
Patients at Risk of Excessive Hypotension
Patients should be followed closely whenever the dose of enalaprilat is adjusted and/or diuretic is increased.
Compatibility and Stability
5 percent Dextrose Injection
Vial - 1.25 mg/mL - 1 mL
Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.]
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