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Usual Diluents


Standard Dilutions   [Amount of drug] [Infusion volume] [Infusion rate]

[Usual dose] [100 ml] [30-60 min]

(Not approved for IV use, however, has been used in patients with insufficient muscle mass.)

Stability / Miscellaneous

Label: Refrigerate
Dosing: (Tuberculosis): 15 mg/kg (Max=1 gram) IM once daily or 25-30 mg/kg administered twice weekly (maximum 1.5 grams/dose) or three times weekly (Maximum 1 gram/dose).

Streptomycin usually replaces ethambutol in the 4 drug regimen [INH, Rifampin, Pyrazinamide, streptomycin].

[CRCL: 10-50// q24-72h or 750mg 2 to 3x/week]
[CRCL < 10// q72-96hrs instead of once daily]

Serum level monitoring: Adjust dose to maintain a trough < 4 mcg/ml.

Source: [package insert]