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Usual Diluents


Standard Dilutions   [Amount of drug] [Infusion volume] [Infusion rate]

 [250,000 u] [50 ml] [30 min]
[1,500,000 u] [50-250ml] [60 min]

Stability / Miscellaneous

Prepare just before use.
Avoid shaking to prevent foaming.

Acute MI: Give 1.5 million IU over 60 minutes.
PE: Loading dose: 250,000 iu over 30 minutes, followed by 100,000 iu/ hr x 24 hours. (x 72 hours for DVT).

Reconstitute the 250, 600, 750k with 5 ml NS. 1.5 mu with 10ml. Do not add more than 1.5 mu to an IV solution (limited stability).

Review contraindications - See Package Insert

Obtain baseline CBC, hct, platelet, PT/PTT, CPK, CPKmb, fibrinogen.
Source: [package insert]