Dilution Lansoprazole

Lansoprazole (Prevacid IV ® )

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Usual Diluents

NS, LR, D5W

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

[30 mg] [50 ml] [30 min]

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Unlabeled Use: GI Bleed
Bolus dose:
[60 mg] [100 ml] [60 min]

Continuous infusion:
[60 mg] [100 ml] [10ml/hr]
= 6 mg/hr.

Stability / Miscellaneous

IMPORTANT:
See Package insert for instructions for Priming the finished admixture and using the provided filter.

Stability:
24 hours (room temperature): if diluted with NS or LR. 12 hour stability if diluted with D5W.

Label: Do not refrigerate. // IN-LINE FILTER MUST BE USED.

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Reconstitution in Vial and Preparation of Admixture:
There are two steps for preparing Prevacid I.V. for Injection.
STEP ONE - Reconstitution in Vial
- First Prevacid I.V. MUST be reconstituted with Sterile Water for Injection, USP.
- Inject 5 mL of ONLY Sterile Water for Injection, USP into a 30 mg vial of PREVACID I.V. for Injection. The resulting solution will contain lansoprazole 6 mg/mL (30 mg/5 mL).
- Failure to reconstitute with Sterile Water may result in formation of precipitation/particulates.
- Mix gently until the powder is dissolved.
The pH of this reconstituted solution is approximately 11. The reconstituted solution can be held for 1 hour when stored at room temperature prior to further dilution.

STEP TWO - Preparation of Admixture
- Dilute the reconstituted solution in either 50 mL of 0.9% Sodium Chloride Injection, USP, Lactated Ringer’s Injection, USP, or 5% Dextrose Injection, USP.

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Treatment of Erosive Esophagitis
The recommended adult dose (when patients are unable to take the oral therapy) is 30 mg of lansoprazole (1 vial of PREVACID I.V. for Injection) per day administered by I.V. infusion over 30 minutes for up to 7 days. Once the patient is able to take medications orally, therapy can be switched to an oral PREVACID formulation for a total of 6 to 8 weeks.

No dosage adjustment is necessary in patients with renal insufficiency or the elderly. For patients with severe liver disease, dosage adjustment should be considered.

Source: [package insert]