Dilution Hydralazine

HYDRALAZINE

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Usual Diluents

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

[0 to 20 mg] [50 ml] [30 min]
[21 to 40 mg] [100 ml] [30 min]
[>40 mg] [250 ml] [60 min or longer]

Monitor BP q5min during initial infusion.

Stability / Miscellaneous

Manufacturer recommends IM or IV push.

Usual dosage: 10 to 40 mg IV q4-6h prn. May be given q20-30 minutes (until adequate response) for the treatment of severe hypertension. IV push (rate): 10 mg/min.

Label: Do not refrigerate. Stability: 24 hours room temperature.

DOSAGE AND ADMINISTRATION
When there is urgent need, therapy in the hospitalized patient may be initiated intramuscularly or as a rapid intravenous bolus injection directly into the vein. Hydralazine hydrochloride injection should be used only when the drug cannot be given orally. The usual dose is 20-40 mg, repeated as necessary.

Certain patients (especially those with marked renal damage) may require a lower dose. Blood pressure should be checked frequently. It may begin to fall within a few minutes after injection, with the average maximal decrease occurring in 10-80 minutes. In cases where there has been increased intracranial pressure, lowering the blood pressure may increase cerebral ischemia. Most patients can be transferred to oral hydralazine hydrochloride within 24-48 hours.

The product should be used immediately after the vial is opened. It should not be added to infusion solutions. Hydralazine hydrochloride injection may discolor upon contact with metal; discolored solutions should be discarded.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Source: [package insert]