Doripenem - DORIBAX™ |
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The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. | |||||||||||||||||||||||||||||||||||
Usual Diluents |
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NS, D5W | |||||||||||||||||||||||||||||||||||
Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate] |
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[ 500 mg ] [ 100 ml ] [ 1 hour ] (Total volume: 110 ml) [ 250 mg ] [ 50 ml ] [ 1 hour ] Reconstitute the 500 mg vial with 10 mL of sterile water or 0.9% NS. |
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Stability / Miscellaneous |
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Renal Dosing:
PREPARATION: Preparation of 250 mg dose for patients with moderate or severe renal impairment: Constitute the vial with 10 mL of sterile water for injection or 0.9% sodium chloride injection (normal saline) and gently shake to form a suspension. The resultant concentration is 50 mg/mL. CAUTION: THE CONSTITUTED SUSPENSION IS NOT FOR DIRECT INJECTION. Withdraw the suspension using a syringe with a 21 gauge needle and add it to an infusion bag containing 100 mL of normal saline or 5% dextrose; gently shake until clear. Remove 55 mL of this solution from the bag and discard. Infuse the remaining solution, which contains 250 mg (4.5 mg/mL). STABILITY:
Source: Ortho-McNeil Pharmaceutical, Inc. (Manufactured by:Shionogi & Co. Ltd). Doripenem (DORIBAX™) [package insert]. Raritan, NJ 08869; 2007. |