GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Emtricitabine/tenofovir disoproxil fumarate (Truvada)

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons

Truvada

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Renal guidance at a glance

Cautions / source differences (1)

Confirm the product, indication and renal measure. The selected summary is not a complete prescribing monograph.

Choose a source to read (3)

Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

1 additional source qualifications - review before use
TRUVADA: treatment interval reduction is not a PrEP strategy

The selected product source has different renal restrictions for treatment and prevention. Its treatment table also identifies ideal (lean) body weight.

Before applying: Confirm indication and source-defined clearance method before selecting an interval; do not transfer the treatment-only reduced-frequency regimen to PrEP.

Also check: TRUVADA: treatment interval reduction is not a PrEP strategy

Rxlist source

GlobalRPh RX List - TRUVADA

Product / population
Adult TRUVADA fixed-dose tablet; HIV treatment and HIV prevention have different renal restrictions.
Renal measure
Estimated creatinine clearance (CrCl), mL/min. The selected subsection does not independently establish an estimating equation. The treatment table footnote specifies ideal (lean) body weight.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

For adult HIV treatment, the 200/300 mg tablet is given every 24 hours at CrCl >=50 mL/min and every 48 hours at 30 to 49. It is not recommended below 30, including hemodialysis. For PrEP, use is not recommended below CrCl 60; do not apply the treatment-only every-48-hour schedule to prevention. Clinical efficacy of the renal interval adjustment has not been evaluated, and pediatric renal dosing data are insufficient.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-08. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/truvada-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

Full source card / provenance

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Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 1 source difference / applicability notes

Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - TRUVADA

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult TRUVADA fixed-dose tablet; HIV treatment and HIV prevention have different renal restrictions.

Renal method: Estimated creatinine clearance (CrCl), mL/min. The selected subsection does not independently establish an estimating equation. The treatment table footnote specifies ideal (lean) body weight.
Retrieved: 2026-09-08

Read local renal resultOpen original reference
Professional guidance

NIH adult ARV table: Emtricitabine/TDF

Adults with HIV; product-specific renal recommendations.

Renal method: CrCl (mL/min), usually Cockcroft-Gault.
Retrieved: 2026-09-05

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Product / population check

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These links compare product identities, not interchangeable doses. A selected summary is not a complete prescribing monograph.

Source-specific review points

TRUVADA: treatment interval reduction is not a PrEP strategy

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Source-quality holds
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No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.

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Jump to renal guidanceRead 1 difference / caution notesClinician guide

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Build a source-review outline for documentation

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Renal-context checklist: population, kidney trend and dialysis

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Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.

See source-specific renal methods and the clinical interpretation guide for the supporting context.

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Source differences and product cautions

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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

indication scope

TRUVADA: treatment interval reduction is not a PrEP strategy

The selected product source has different renal restrictions for treatment and prevention. Its treatment table also identifies ideal (lean) body weight.

How to use this: Confirm indication and source-defined clearance method before selecting an interval; do not transfer the treatment-only reduced-frequency regimen to PrEP.

GlobalRPh RX List - TRUVADAEmtricitabine / tenofovir alafenamide - DESCOVYEmtricitabine / rilpivirine / TDF - COMPLERA

Source-specific interpretation; independent clinician adjudication pending.

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Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.
Rxlist source

GlobalRPh RX List - TRUVADA

Adult TRUVADA fixed-dose tablet; HIV treatment and HIV prevention have different renal restrictions.

Method: Estimated creatinine clearance (CrCl), mL/min. The selected subsection does not independently establish an estimating equation. The treatment table footnote specifies ideal (lean) body weight.

Renal dosing, restrictions and evidence limitsRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeGlobalRPh RX List - TRUVADANIH adult ARV table: Emtricitabine/TDF
Choose two source checkboxes below.
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Historical treatment-oriented fixed-combination table. Do not apply this renal interval to HIV PrEP or to tenofovir alafenamide combinations.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/truvada/

Usual Dosing (Adults)

Adults and pediatric patients at least 12 years and at least 35 kg: one tablet containing emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg orally once daily with or without food.

GRPH-truvada-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl above 50 mL/min: no change. 30-49: one tablet every 48 hours. Below 30: not recommended. Exactly 50 is not assigned in the original summary.

GRPH-truvada-02 · Source section: Renal DosingRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - TRUVADA

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GlobalRPh-hosted RX List · Adult TRUVADA fixed-dose tablet; HIV treatment and HIV prevention have different renal restrictions.

Renal method: Estimated creatinine clearance (CrCl), mL/min. The selected subsection does not independently establish an estimating equation. The treatment table footnote specifies ideal (lean) body weight.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-08

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For adult HIV treatment, the 200/300 mg tablet is given every 24 hours at CrCl >=50 mL/min and every 48 hours at 30 to 49. It is not recommended below 30, including hemodialysis. For PrEP, use is not recommended below CrCl 60; do not apply the treatment-only every-48-hour schedule to prevention. Clinical efficacy of the renal interval adjustment has not been evaluated, and pediatric renal dosing data are insufficient.

RDM45-rxlist-truvada-5669425f1b-C1 · Source locator: Dosage Adjustment for Renal Impairment and Table 1, lines 85-101.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/truvada-drug/
Retrieved
2026-09-08
Renal-function method
Estimated creatinine clearance (CrCl), mL/min. The selected subsection does not independently establish an estimating equation. The treatment table footnote specifies ideal (lean) body weight.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
9b3a681c623666009754fa9c8129bbdc8b5db0df9c4e052917d0d9d4aa3468b9
Separate professional-source layer

University and professional protocols

Professional

NIH adult ARV table: Emtricitabine/TDF

Open original reference

Open / share this exact local source

NIH ClinicalInfo HIV guidelines · Adults with HIV; product-specific renal recommendations.

Renal method: CrCl (mL/min), usually Cockcroft-Gault.
Source date: Not established
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

NIH dose and renal statement

HIV treatment: one tablet daily; CrCl 30-49: every 48 hours; <30 or HD: not recommended. This is not PrEP guidance.

truvada:nih-arv-truvada-1 · Source locator: Appendix B: Emtricitabine/TDF row

Source identity and provenance
Source
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/drug-characteristics-tables-renal-hepatic-insufficiency-full
Retrieved
2026-09-05
Renal-function method
CrCl (mL/min), usually Cockcroft-Gault.
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
c5f8ca9aa4b655fb46798d09e4d2bcd305198975570fdfe2dc6e2d0cebabe158

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/truvada/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
7ff6f76a9ea2b7f7c07b58d019d9c539cf471941d0665d0085910ea81e9beefe
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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