GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Tadalafil - ADCIRCA PAH tablets

Local RX List renal extractBase record retrieved 2026-09-09See the evidence for this drug1 sources available - open source summaries, references and comparisons

ADCIRCA / ADCIRCA PAH / tadalafil tablets

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Renal guidance at a glance

Cautions / source differences (1)
Review first - source-specific qualification

PAH scope and an unassigned exact CrCl boundary

The source uses PAH-specific daily instructions and leaves an exact boundary unstated in its numeric dosage bands.

Before applying: Do not insert an ED schedule or silently interpolate the boundary. Obtain product-specific clarification.

Evidence for this qualification

Source-specific qualification; independent clinician review pending.

Confirm the product, indication and renal measure. The selected summary is not a complete prescribing monograph.

Choose a source to read (1)

Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

Rxlist source

GlobalRPh RX List - ADCIRCA

Product / population
ADCIRCA tablets for WHO Group 1 pulmonary arterial hypertension; not as-needed erectile dysfunction or a fixed-combination tadalafil product.
Renal measure
CrCl, mL/min; exact 30 mL/min is not assigned in the printed dosage bands

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Selected sections only. Source mirror and underlying label are not independent confirmations.

Renal dosing, restrictions and evidence limits

For PAH, the source starts patients with CrCl 51-80 or 31-50 mL/min at 20 mg once daily, with an increase to 40 mg once daily according to tolerability. Severe impairment is an avoidance setting; the dosage section prints CrCl <30 mL/min and hemodialysis, and the renal-use section advises avoidance in severe impairment. Dialysis does not meaningfully correct exposure.

The printed bands do not assign exactly 30 mL/min. No boundary is filled in here. These are PAH instructions, not an as-needed erectile-dysfunction schedule.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-09. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/adcirca-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

Full source card / provenance

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Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 1 source difference / applicability notes

GlobalRPh RX List

GlobalRPh RX List - ADCIRCA

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

ADCIRCA tablets for WHO Group 1 pulmonary arterial hypertension; not as-needed erectile dysfunction or a fixed-combination tadalafil product.

Renal method: CrCl, mL/min; exact 30 mL/min is not assigned in the printed dosage bands
Retrieved: 2026-09-09

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Product / population check

Confirm the exact formulation before using a renal source

These links compare product identities, not interchangeable doses. A selected summary is not a complete prescribing monograph.

Source-specific review points

PAH scope and an unassigned exact CrCl boundary

Read the attributed comparison notes and source cards below. No conflict has been silently adjudicated.

Source-quality holds
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Search the stored clinical text

Locate a word or phrase within this drug's source summaries. Choose all sources or one source to focus the search. The selection never hides warnings or source text, changes a dose, or proves that a renal finding is absent.

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All source summaries, original wording and provenance
Before applying a renal protocol

Check the setting. Compare whole sources.

No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.

Share a reproducible source review

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Jump to renal guidanceRead 1 difference / caution notesClinician guide

Only one eligible source version is stored here. No second source is inferred from a reference link. Independent corroboration is still needed.

Build a source-review outline for documentation

This creates a blank decision outline with the source identities you select, not a dose recommendation or completed clinical assessment. No patient fields are collected, saved or sent. Complete the clinical decisions in your approved documentation system.

Choose one or two sources above or use the source checkboxes below.

Renal-context checklist: population, kidney trend and dialysis

These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.

Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.

See source-specific renal methods and the clinical interpretation guide for the supporting context.

Read before choosing a regimen

Source differences and product cautions

Search differences across all drugs

These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

Go directly to the relevant source section

Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeGlobalRPh RX List - ADCIRCA
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/adcirca-drug/

Exact product and population

ADCIRCA tablets for WHO Group 1 pulmonary arterial hypertension; not as-needed erectile dysfunction or a fixed-combination tadalafil product.

RDM54-SCOPE-tadalafil-adcirca-pah · Source section: Selected source product scopeRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - ADCIRCA

Open original reference

Open / share this exact local source

GlobalRPh-hosted RX List · ADCIRCA tablets for WHO Group 1 pulmonary arterial hypertension; not as-needed erectile dysfunction or a fixed-combination tadalafil product.

Renal method: CrCl, mL/min; exact 30 mL/min is not assigned in the printed dosage bands
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-09

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For PAH, the source starts patients with CrCl 51-80 or 31-50 mL/min at 20 mg once daily, with an increase to 40 mg once daily according to tolerability. Severe impairment is an avoidance setting; the dosage section prints CrCl <30 mL/min and hemodialysis, and the renal-use section advises avoidance in severe impairment. Dialysis does not meaningfully correct exposure.

The printed bands do not assign exactly 30 mL/min. No boundary is filled in here. These are PAH instructions, not an as-needed erectile-dysfunction schedule.

RDM54-rxlist-tadalafil-adcirca-pah-d30a0fae71-C1 · Source locator: Dosage and Administration; Renal Impairment; selected Warnings and Precautions

Source-specific limits

Selected sections only. Source mirror and underlying label are not independent confirmations.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/adcirca-drug/
Retrieved
2026-09-09
Renal-function method
CrCl, mL/min; exact 30 mL/min is not assigned in the printed dosage bands
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
fb8dc88e812dd4310f167ed3299e0e36712ab3020cee38c49ef450938a870b8c

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/adcirca-drug/
Source retrieval
2026-09-09. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
ea18535a2d1c1ffcf888333c35c26773f8ec2bb82193b71ccb384a1562b04085
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

Read the full coverage report