Original GlobalRPh source
- Product / population
- Preserved GlobalRPh source, not a freshly verified product label
- Renal measure
- Use the method specified in the original source
Historical source: not automatically current. Review current official labeling and separately attributed additions before use.
The qualitative contraindications and alternative interval table are distinct original statements. The alternative does not override a contraindication or potassium monitoring.
Usual Dosing (Adults)
Edema from CHF, cirrhosis or nephrotic syndrome: initially 100 mg/day once or divided; source range 25-200 mg/day. As sole diuretic continue the starting dose for at least 5 days before optimizing. Hypertension: start 50-100 mg/day once or divided; may combine with more proximally acting diuretics or other antihypertensives. Allow at least 2 weeks because maximal response may be delayed. Diuretic-induced hypokalemia: 25-100 mg/day when potassium supplementation or other potassium-sparing approaches are inappropriate.
Renal Dosing
The original contraindications are anuria, acute renal insufficiency, significant impairment of renal excretory function or hyperkalemia. It also lists an alternative: CrCl above 50 mL/min no change; 10-50, every 12-24 hours; below 10, avoid.
Hemodialysis
Avoid.