Incision and drainage first
Outpatient treatment:
Unresolving:
Bactrim DS orally twice daily
OR
Clindamycin 300mg orally four times daily or if severe 600mg IV every 6 hours
OR
Doxycycline 100mg orally twice daily for 7-10 days.
OR
Cephalexin (Keflex ®) 500mg orally every 6 hours
OR
Dicloxacillin 500mg orally four times daily
Hospitalized Patient:
Vancomycin 1 gram ivpb q12h (patient-specific dosing required - target trough 10-20 mcg/ml depending on severity)
Documented MSSA:
Cefazolin 1 gram IVPB q8h or consider oral agent above.
MRSA:
Daptomycin 4 mg/kg IV q 24h OR
Linezolid 600 mg orally or IV q 12h OR
Ceftaroline 600mg IV q12h.
