Ceftriaxone

Usual Dosing (Adults)

Adults

The usual adult daily dose is 1 to 2 grams given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. For infections caused by Staphylococcus aureus (MSSA), the recommended daily dose is 2 to 4 grams, in order to achieve >90% target attainment. The total daily dose should not exceed 4 grams.

If Chlamydia trachomatis is a suspected pathogen, appropriate antichlamydial coverage should be added, because ceftriaxone sodium has no activity against this organism.

For the treatment of uncomplicated gonococcal infections, a single intramuscular dose of 250 mg is recommended.

For preoperative use (surgical prophylaxis), a single dose of 1 gram administered intravenously 1/2 to 2 hours before surgery is recommended.

Generally, Ceftriaxone for Injection, USP therapy should be continued for at least 2 days after the signs and symptoms of infection have disappeared. The usual duration of therapy is 4 to 14 days; in complicated infections, longer therapy may be required.

When treating infections caused by Streptococcus pyogenes, therapy should be continued for at least 10 days.

No dosage adjustment is necessary for patients with impairment of renal or hepatic function.

Renal Dosing

No adjustments are necessary, however, blood levels are recommended in dialysis patients. Adults with both renal and hepatic failure should not receive more than 2 gm/day

Hemodialysis

Hemodialysis:
No specific recommendations per manufacturer except that blood levels are recommended in dialysis patients. The dosage should not exceed 2 grams per day.

PD: 750mg q12h.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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