Wound infections

Wound Infections

Wound infections

Possible therapeutic alternatives

Wound: Infected, post-op or trauma, without sepsis. (Not Gastrointestinal tract or female genital tract.)

Bactrim DS orally twice daily OR

Cephalexin 500mg orally 4 times daily OR

Augmentin 875/125 mg orally twice daily OR500/125mg three times daily or
Augmentin XR* 1000/62.5 mg 2 tablets orally twice daily OR

*AUGMENTIN XR is contraindicated in patients with a creatinine clearance of < 30 mL/min. and in hemodialysis patients.

Doxycycline 100mg orally twice daily OR

Clindamycin 300mg to 450mg orally four times daily

Ticarcillin-clavulanic acid 3.1 grams IV every 6 hours OR
Piperacillin-tazobactam 3.375 grams IV every 6 hours OR
Ertapenem 1 gram q24h

PLUS
Vancomycin 1 gram ivpb q12h (patient-specific dosing required)

Wound infection + sepsis. (does not include surgery involving GI or female genital tract)

Ampicillin-sulbactam 1.5 - 3 grams IV every 6 hours OR

Ticarcillin-clavulanic acid 3.1 grams IV every 6 hours OR

Piperacillin-tazobactam 3.375 grams IV every 6 hours OR

Cefazolin 1 gram IV every 8 hours.

Postop wound (surgery involving gastrointestinal tract or female genital tract) (all regimens must cover anaerobes)

Piperacillin-tazobactam 3.375 grams IV every 6 hours OR

Ticarcillin-clavulanic acid 3.1grams IV every 6 hours OR

Ampicillin-sulbactam 1.5-3g ivpb q6h OR

[ (Cefotaxime 1g ivpb q8h or Ceftriaxone1-2g ivpb q24h ) + Metronidazole 500mg ivpb q6-8h] OR

Imipenem 500mg ivpb q6h.