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Drug Description

DESCRIPTION

TONOCARD*(Tocainide HCl) is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. The chemical name for tocainide hydrochloride is 2-amino-N-(2,6-dimethylphenyl) propanamide hydrochloride. Its empirical formula is C11H16N2O † HCl, with a molecular weight of 228.72.

Tocainide hydrochloride is a white crystalline powder with a bitter taste and is freely soluble in water. It is supplied as 400 mg and 600 mg tablets for oral administration. Each tablet contains the following inactive ingredients: hydroxypropyl methylcellulose, iron oxide, magnesium stearate, methylcellulose, polyethylene glycol, and titanium dioxide.

Indications

INDICATIONS

TONOCARD (tocainide hcl) is indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening. Because of the proarrhythmic effects of TONOCARD, (tocainide hcl) as well as its potential for other serious adverse effects, (see WARNINGS), its use to treat lesser arrhythmias is not recommended. Treatment of patients with asymptomatic ventricular premature contractions should be avoided.

Initiation of treatment with TONOCARD, (tocainide hcl) as with other antiarrhythmic agents used to treat life-threatening arrhythmias, should be carried out in the hospital. It is essential that each patient given TONOCARD (tocainide hcl) be evaluated electrocardiographically and clinically prior to, and during, therapy with TONOCARD (tocainide hcl) to determine whether the response to TONOCARD (tocainide hcl) supports continued treatment.

Antiarrhythmic drugs have not been shown to enhance survival in patients with ventricular arrhythmias.

QUESTION

About how much does an adult human brain weigh? See Answer
Dosage

DOSAGE AND ADMINISTRATION

The dosage of TONOCARD (tocainide hcl) must be individualized on the basis of antiarrhythmic response and tolerance, both of which are dose-related. Clinical and electrocardiographic evaluation (including Holter monitoring if necessary for evaluation) are needed to determine whether the desired antiarrhythmic response has been obtained and to guide titration and dose adjustment. Adverse effects appearing shortly after dosing, for example, suggest a need for dividing the dose further with a shorter dose-interval. Loss of arrhythmia control prior to the next dose suggests use of a shorter dose interval and/or a dose increase. Absence of a clear response suggests reconsideration of therapy.

The recommended initial dosage is 400 mg every 8 hours. The usual adult dosage is between 1200 and 1800 mg/day in a three dose daily divided regimen. Doses beyond 2400 mg per day have been administered infrequently. Patients who tolerate the t.i.d. regimen may be tried on a twice daily regimen with careful monitoring.

Some patients, particularly those with renal or hepatic impairment, may be adequately treated with less than 1200 mg/day.

HOW SUPPLIED

No. 3409† Tablets TONOCARD, (tocainide hcl) 400 mg, are oval, yellow, scored, film-coated tablets, coded 707 on one side and TONOCARD (tocainide hcl) on the other side. They are supplied as follows:

    NDC 61113-707-68 bottles of 100
    (6505-01-203-6240, 400 mg 100†s)
    NDC 61113-707-28 unit dose packages of 100

No. 3410 † Tablets TONOCARD, (tocainide hcl) 600 mg, are oblong, yellow, scored, film-coated tablets, coded 709 on one side and TONOCARD (tocainide hcl) on the other side. They are supplied as follows:

    NDC 61113-709-68 bottles of 100
    (6505-01-206-0273, 600 mg 100†s)
    NDC 61113-709-28 unit dose packages of 100;

Storage

Store below 40°C (104°F); preferably between 15°C and 30°C (59°F and 86°F). Store in a well-closed container.

Side Effects

SIDE EFFECTS

TONOCARD (tocainide hcl) commonly produces minor, transient, nervous system and gastrointestinal adverse reactions, but is otherwise generally well tolerated. TONOCARD (tocainide hcl) has been evaluated in both short-term (n = 1,358) and long-term (n = 262) controlled studies as well as a compassionate use program. Dosages were lower in most of the controlled studies (1200 mg/day) and higher in the compassionate use program (1800 mg and more). In long-term (2-6 months) controlled studies, the most frequent adverse reactions were dizziness/vertigo (15.3 percent), nausea, (14.5 percent), paresthesia (9.2 percent), and tremor (8.4 percent). These reactions were generally mild, transient, dose-related and reversible with a reduction in dosage, by taking the drug with food, or by therapy discontinuation. Tremor, when present, may be useful as a clinical indicator that the maximum dose is being approached. Adverse reactions leading to therapy discontinuation occurred in 21 percent of patients in long-term controlled trials and were usually related to the nervous system or digestive system.

Adverse reactions occurring in greater than one percent of patients from the short-term and long-term controlled studies appear in the following table:

Body System /
Adverse REACTIONS
Percent of Patients
Controlled Studies
Short-term (n=1,358) Long-term (n=262)
BODY AS A WHOLE 
Tiredness/drowsiness/fatigue/lethargy/lassitude/sleepiness 1.6

0.8

Hot/cold feelings 0.5 1.5 
CARDIOVASCULAR 
Hypotension 3.4

2.7

Bradycardia 1.8

0.4

Palpitations 1.8 0.4 
Chest pain 1.6 0.4
Conduction disorders 1.5 0.0
Left ventricular failure  1.4 0.0
DIGESTIVE
Nausea 15.2 14.5
Vomiting  8.3 4.6
Anorexia  1.2 1.9
Diarrhea/ loose stools 0.0 3.8
NERVOUS  SYSTEM/PSYCHIATRIC
Dizziness/vertigo  8.0 15.3
Paresthesia 3.5 9.2
Tremor 2.9 8.4
Confusion/disorientation/hallucinations 2.1 2.7
Headache 2.1 4.6
Nervousness 1.5 0.4
Altered mood/awareness 1.5 3.4
Incoordination/unsteadiness/walking disturbances 1.2 0.0
Anxiety 1.1 1.5
Ataxia 0.2 3.0
SKIN
Diaphoresis 5.1 2.3
Rash/skin lesion 0.4 8.4
SPECIAL SENSES
Blurred vision/visual disturbances 1.3 1.5
Tinnitus/hearing loss 0.4 1.5
Nystagmus  0.0 1.1

An additional group of about 2,000 patients has been treated in a program allowing for the use of TONOCARD (tocainide hcl) under compassionate use circumstances. These patients were seriously ill with the large majority on multiple drug therapy, and comparatively high doses of TONOCARD (tocainide hcl) were used. Fifty-four percent of the patients continued in the program for one year or longer, and 12 percent were treated for longer than three years, with the longest duration of therapy being nine years. Adverse reactions leading to therapy discontinuation occurred in 12 percent of patients (usually central nervous system effects or rash). A tabulation of adverse reactions occurring in one percent or more of patients follows:

Body System /
Adverse REACTIONS
Percent of Patients Compassionate Use (n=1,927)
CARDIOVASCULAR 
Increased ventricular arrhythmias/PVCs

10.9

CHF/progression of CHF

4.0

Tachycardia 3.2
Hypotension  1.8
Conduction disorders

1.3

Bradycardia

1.0

DIGESTIVE 
Nausea  24.6
Anorexia 

11.3

Vomiting 9.0
Diarrhea/loose stools 6.8
MUSCULOSKELETAL 
Arthritis/arthralgia 4.7
Myalgia  1.7
NERVOUS SYSTEM/PSYCHIATRIC 
Dizziness/vertigo 25.3
Tremor 21.6
Nervousness 11.5
Confusion/disorientation/hallucinations

 11.2

Altered mood/awareness 11.0
Ataxia 10.8
Paresthesia  9.2
SKIN 
Rash/Skin lesion

12.2

Diaphoresis

8.3

Lupus 1.6
SPECIAL SENSES 
Blurred vision/vision disturbances 10.0
Nystagmus  1.1

Adverse reactions occurring in less than one percent of patients, in either the controlled studies on the compassionate use program or since the drug was marketed, are as follows:

Body as a Whole: Septicemia; septic shock; syncope; vasovagal episodes; edema; fever; chills; cinchonism; asthenia; malaise.

Cardiovascular: Ventricular fibrillation; extension of acute myocardial infarction; cardiogenic shock; pulmonary embolism; angina; AV block; hypertension; claudication; increased QRS duration; pleurisy/pericarditis; prolonged QT interval; right bundle branch block; cardiomegaly; sinus arrest; vasculitis; orthostatic hypotension; cold extremities.

Digestive: Hepatitis, jaundice (see PRECAUTlONS), abnormal liver function tests, pancreatitis, abdominal pain and discomfort; constipation; dysphagia; gastrointestinal symptoms (including dyspepsia); stomatitis; dry mouth; thirst.

Hematologic: Agranulocytosis; bone marrow depression; aplastic/hypoplastic anemia; hemolytic anemia; anemia; leukopenia; neutropenia; thrombocytopenia; eosinophilia.

Metabolic and Immune: Hypersensitivity Reaction (including some of the following symptoms or signs: rash, fever, joint pains, abnormal liver function tests, eosinophilia); increased ANA.

Musculoskeletal: Muscle cramps; muscle twitching/spasm; neck pain; pain radiating from neck pressure on shoulder.

Nervous System/Psychiatric: Coma; convulsions/seizures; myasthenia gravis; depression; psychosis; psychic disturbances; agitation; decreased mental acuity; dysarthria; impaired memory; increased stuttering/slurred speech; insomnia/sleeping disturbances; local anesthesia; dream abnormalities.

Respiratory: Respiratory arrest; pulmonary edema; pulmonary fibrosis; fibrosing alveolitis; pneumonia; interstitial pneumonitis; dyspnea; hiccups; yawning.

Skin: Stevens-Johnson syndrome; exfoliative dermatitis; erythema multiforme; urticaria; alopecia; pruritus; pallor/flushed face.

Special Senses: Diplopia; earache; taste perversion/smell perversion.

Urogenital: Urinary retention; polyuria/increased diuresis.

Agranulocytosis, bone marrow depression, leukopenia, neutropenia, aplastic/hypoplastic anemia, and thrombocytopenia have been reported (0.18 percent) in patients receiving TONOCARD (tocainide hcl) in controlled trials and the compassionate use program. Most of these events have been noted during the first 12 weeks of therapy. (See Boxed WARNINGS.)

Pulmonary fibrosis, interstitial pneumonitis, fibrosing alveolitis, pulmonary edema, and pneumonia, have been reported in patients receiving TONOCARD. (tocainide hcl) The incidence of pulmonary fibrosis (including interstitial pneumonitis and fibrosing alveolitis) was 0.11 percent in controlled trials and the compassionate use program. These events usually occurred in seriously ill patients. Symptoms of these pulmonary disorders and/or x-ray changes usually occurred following 3-18 weeks of therapy. Fatalities have been reported. (See Boxed WARNINGS.)

A number of disorders, in which a causal relationship with TONOCARD (tocainide hcl) has not been established, have been reported in seriously ill patients. These include: renal failure; renal dysfunction; myocardial infarction; cerebrovascular accidents and transient ischemic attacks. These disorders may be related to the patient†s underlying condition.

DRUG ABUSE AND DEPENDENCE

Drug withdrawal after chronic treatment has not shown any indication of psychological or physical dependence.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Drug Interactions

DRUG INTERACTIONS

Tocainide and lidocaine are pharmacodynamically similar. The concomitant use of these two agents may cause an increased incidence of adverse reactions, including central nervous system adverse reactions such as seizure.

Specific interaction studies with cimetidine, digoxin, metoprolol and warfarin have been conducted, no clinically significant interaction was seen with cimetidine, digoxin or warfarin; but tocainide and metoprolol had additive effects on wedge pressure and cardiac index. TONOCARD (tocainide hcl) has also been used in open studies with digitalis, beta-blocking agents, other antiarrhythmic agents, anticoagulants, and diuretics, without evidence of clinically significant interactions. Nevertheless, caution should be exercised in the use of multiple drug therapy.

TONOCARD (tocainide hcl) is equally effective in digitalized and non-digitalized patients. In 17 patients with refractory ventricular arrhythmias on concomitant therapy, serum digoxin levels (1.1 ±0.4 ng/mL) remained in the expected normal range (0.5-2.5 ng/mL) during tocainide administration.

Warnings

WARNINGS

WARNINGS

 

Blood Dyscrasias: Agranulocytosis, bone marrow depression, leukopenia, neutropenia, aplastic/hypoplastic anemia, thrombocytopenia and sequelae such as septicemia and septic shock have been reported in patients receiving TONOCARD. (tocainide hcl) Most of these patients received TONOCARD (tocainide hcl) within the recommended dosage range. Fatalities have occurred (with approximately 25 percent mortality in reported agranulocytosis cases). Since most of these events have been noted during the first 12 weeks of therapy, it is recommended that complete blood counts, including white cell, differential and platelet counts be performed, optimally, at weekly intervals for the first three months of therapy; and frequently thereafter. Complete blood counts should be performed promptly if the patient develops any signs of infection (such as fever, chills, sore throat, or stomatitis), bruising, or bleeding. If any of these hematologic disorders is identified, TONOCARD (tocainide hcl) should be discontinued and appropriate treatment should be instituted if necessary. Blood counts usually return to normal within one month of discontinuation. Caution should be used in patients with pre-existing marrow failure or cytopenia of any type. (See ADVERSE REACTIONS.) 

Pulmonary Fibrosis: Pulmonary fibrosis, interstitial pneumonitis, fibrosing alveolitis, pulmonary edema, and pneumonia have been reported in patients receiving TONOCARD. (tocainide hcl) Many of these events occurred in patients who were seriously ill. Fatalities have been reported. The experiences are usually characterized by bilateral infiltrates on x-ray and are frequently associated with dyspnea and cough. Fever may or may not be present. Patients should be instructed to promptly report the development of any pulmonary symptoms such as exertional dyspnea, cough or wheezing. Chest x-rays are advisable at that time. If these pulmonary disorders develop, TONOCARD should be discontinued. (See ADVERSE REACTIONS.)

 

Mortality: In the National Heart, Lung and Blood Institute†s Cardiac Arrhythmia Suppression Trial (CAST), a long-term, multi-center, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had a myocardial infarction more than six days but less than two years previously, an excessive mortality or non-fatal cardiac arrest rate (7.7%) was seen in patients treated with encainide or flecainide compared with that seen in patients assigned to carefully matched placebo-treated groups (3.0%). The average duration of treatment with encainide or flecainide in this study was ten months. 
The applicability of the CAST results to other populations (e. g., those without recent myocardial infarction) is uncertain. Considering the known proarrhythmic properties of TONOCARD (Tocainide HCl) and the lack of evidence of improved survival for any antiarrhythmic drug in patients without life- threatening arrhythmias, the use of TONOCARD as well as other antiarrhythmic agents should be reserved for patients with life-threatening ventricular arrhythmias.

Acceleration of Ventricular Rate: Acceleration of ventricular rate occurs infrequently when antiarrhythmics are administered to patients with atrial flutter or fibrillation (see ADVERSE REACTIONS).

Precautions

PRECAUTIONS

General

In patients with known heart failure or minimal cardiac reserve, TONOCARD (tocainide hcl) should be used with caution because of the potential for aggravating the degree of heart failure.

Caution should be used in the institution or continuation of antiarrhythmic therapy in the presence of signs of increasing depression of cardiac conductivity.

In patients with severe liver or kidney disease, the rate of drug elimination may be significantly decreased (see DOSAGE AND ADMINISTRATION).

Since antiarrhythmic drugs may be ineffective in patients with hypokalemia, the possibility of a potassium deficit should be explored and, if present, the deficit should be corrected.

Like all other oral antiarrhythmics, TONOCARD (tocainide hcl) has been reported to increase arrhythmias in some patients (see ADVERSE REACTIONS).

Information for Patients

See PATIENT INFORMATION section.

Laboratory Tests

As with other antiarrhythmics, abnormal liver function tests, particularly in the early stages of therapy, have been reported. Periodic monitoring of liver function should be considered. Hepatitis and jaundice have been reported in some patients.

Drug Interactions

See DRUG INTERACTIONS section.

Carcinogenesis, Mutagenesis, Impairment of Fertility

The carcinogenic potential of tocainide was studied in mice using oral doses up to 300 mg/kg/day (about 6 times the maximum recommended human dose) for up to 94 weeks in males and 102 weeks in females and in rats at doses up to 200 mg/kg/day for 24 months. Tocainide did not affect the type or incidence of neoplasia in the two studies.

Tocainide did not show any mutagenic potential when evaluated in vivo in the micronucleus test using mice at oral doses up to 187.5 mg/kg/day (about 7 times the usual human dose). Also, no mutagenic activity was seen in vitro in the Ames microbial mutagen test or in the mouse lymphoma forward mutation assay.

Reproduction and fertility studies in rats showed no adverse effects on male or female fertility at oral doses up to 200 mg/kg/day (about 8 times the usual human dose).

Pregnancy

Pregnancy Category C. In a teratogenicity study in rabbits, tocainide was administered orally at doses of 25, 50, and 100 mg/kg/day (about 1 to 4 times the usual human dose). No evidence of a drug-related teratogenic effect was noted; however, these doses were maternotoxic and produced a dose-related increase in abortions and stillbirths. In a teratogenicity study in rats, an oral dose of 300 mg/kg/day (about 12 times the usual human dose) showed no evidence of treatment-related fetal malformations, but maternotoxicity and an increase in fetal resorptions were noted. An oral dose of 30 mg/kg/day (about twice the usual human dose) did not produce any adverse effects.

In reproduction studies in rats at maternotoxic oral doses of 200 and 300 mg/kg/day (about 8 and 12 times the usual human dose, respectively), dystocia, and delayed parturition occurred which was accompanied by an increase in stillbirths and decreased survival in offspring during the first week postpartum. Growth and viability of surviving offspring were not affected for the remainder of the lactation period.

There are no adequate and well-controlled studies in pregnant women. TONOCARD (tocainide hcl) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

It is not known whether tocainide is secreted in human milk. Because many drugs are secreted in human milk and because of the potential for serious adverse reactions in nursing infants from TONOCARD, (tocainide hcl) a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Safety and effectiveness in children have not been established.

Overdosage & Contraindications

OVERDOSE

The initial and most important signs and symptoms of. overdosage would be expected to be related to the central nervous system. Other adverse reactions, such as gastrointestinal disturbances, may follow. (See ADVERSE REACTIONS.)

Should convulsions or cardiopulmonary depression or arrest develop, the patency of the airway and adequacy of ventilation must be assured immediately. Should convulsions persist, despite ventilatory therapy with oxygen, small increments of anticonvulsive agents may be given intravenously. Examples of such agents include a benzodiazepine (e.g., diazepam), an ultrashort-acting barbiturate (e.g., thiopental or thiamylal), or a short-acting barbiturate (e.g., pentobarbital or secobarbital).

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Studies in normal individuals to date indicate that tocainide has a hemodialysis clearance approximately equivalent to its renal clearance.

CONTRAINDICATIONS

Patients who are hypersensitive to this product or to local anesthetics of the amide type.

Patients with second or third degree atrioventricular block in the absence of an artificial ventricular pacemaker.

QUESTION

About how much does an adult human brain weigh? See Answer
Clinical Pharmacology

CLINICAL PHARMACOLOGY

Action

Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue.

Electrophysiology

Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

In studies of isolated dog Purkinje fibers, tocainide in concentrations of 1-50 mcg/mL had no significant effect on resting membrane potential, but reduced the amplitude and rate of depolarization (dv/dt) of the action potential. Tocainide decreased the effective refractory period (ERP) to a lesser extent than the action potential duration (APD) resulting in an increase in the ERP/APD ratio.

In patients with cardiac disease, TONOCARD (tocainide hcl) produced no clinically significant changes in sinus nodal function, effective refractory periods, or intracardiac conduction times when studied under electrophysiologic testing procedures.

Tocainide, like lidocaine, characteristically does not prolong ventricular depolarization (QRS duration) or repolarization (QT intervals) as measured by electrocardiography. Theoretically, therefore, TONOCARD (tocainide hcl) may be useful in the treatment of ventricular arrhythmias associated with a prolonged QT interval.

Patients who respond to lidocaine also respond to TONOCARD (tocainide hcl) in a majority of cases. Failure to respond to lidocaine usually predicts failure to respond to TONOCARD, (tocainide hcl) but there are exceptions to this.

In a controlled comparison with quinidine, 600 mg b.i.d. of TONOCARD (tocainide hcl) produced a mean reduction of 42 percent in PVC count, compared to a 54 percent reduction by quinidine 300 mg every 6 hours. Among all patients entered into the study, about one-fifth of tocainide recipients and one-third of quinidine recipients had 75 percent or greater reductions in PVC count or had elimination of ventricular tachycardia.

Pharmacokinetics

Following oral administration of tocainide, peak plasma concentrations occur within 0.5 to 2 hours. The average plasma half-life in patients is approximately 15 hours. Although the effective plasma concentration may vary from patient to patient, the usual therapeutic plasma range (as defined by 50-80 percent PVC suppression) is 4-10 mcg/mL (18-45 micromole/L), expressed as tocainide hydrochloride. Tocainide is approximately 10 percent bound to plasma protein.

In contrast to lidocaine, tocainide undergoes negligible first pass hepatic degradation. Following oral administration, the bioavailability of TONOCARD (tocainide hcl) approaches 100 percent. The extent of its bioavailability is unaffected by food. Tocainide has no cardioactive metabolites. Approximately 40 percent of the administered dose of tocainide is excreted unchanged in the urine. Acidification of the urine has not been shown to significantly alter tocainide excretion in the urine, but alkalinization of the urine results in a significant decrease in the percent of tocainide excreted unchanged in the urine. Animal data indicate that tocainide crosses the blood-brain barrier; however, it has less lipid solubility than lidocaine.

Hemodynamics

Cardiac catheterization studies in man utilizing intravenous tocainide infusions (0.5-0.75 mg/kg/mm over 15 min) have shown that tocainide usually produces a small degree of depression of parameters of left ventricular function, such as left ventricular dP/dt, and left ventricular end diastolic pressure. There were usually no changes in cardiac output or clinical evidence of increasing congestive heart failure in the well-compensated patients studied. Small but statistically significant increases in aortic and pulmonary arterial pressures have been consistently observed and are probably related to small increases in vascular resistance. When used concomitantly with a beta-blocking drug, tocainide further reduced cardiac index and left ventricular dP/dt and further increased pulmonary wedge pressure.

No clinically significant changes in heart rate, blood pressure, or signs of myocardial depression were observed in a study of 72 post-myocardial infarction patients receiving long-term therapy with oral TONOCARD (tocainide hcl) at usual doses (400 mg q8h). When tocainide was administered orally at a dose of 120 mg/kg to anesthetized dogs (14 times the initial maximum dose recommended for humans), a negative inotropic effect was observed: the rate of change of left ventricular pressure decreased by up to 29 percent of control at 3 hours after administration. This effect was not observed at lower doses (60 mg/kg). Tocainide has been used safely in patients with acute myocardial infarction and various degrees of congestive heart failure. It has, however, a small negative inotropic effect and can increase peripheral resistance slightly. It therefore should be used cautiously in patients with known heart failure, particularly if a beta-blocker is given as well. (See PRECAUTIONS.)

Medication Guide

PATIENT INFORMATION

Patients should be instructed to promptly report the development of bruising or bleeding; any signs of infections such as fever, chills, sore throat, or soreness and ulcers in the mouth; any pulmonary symptoms, such as exertional dyspnea, cough, or wheezing; rash.

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