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Usual Dosing (Adults)

Colorectal / Breast cancer: Recommended dose: 1250 mg/m2 po bid (morning and evening; equivalent to 2500 mg/m 2 total daily dose) x 2 weeks followed by a 1-week rest period given as 3-week cycles. Tablets should be swallowed with water within 30 minutes after a meal. In combination with docetaxel, the recommended dose of XELODA is 1250 mg/m2 bid x 2 weeks followed by a 1-week rest period, combined with docetaxel at 75 mg/m2 as a 1-hour intravenous infusion every 3 weeks. 

Maintenance dose: Subsequent dose adjustment is recommended as outlined in the package insert if a patient develops a grade 2 to 4 adverse event. SEE PACKAGE INSERT FOR DOSAGE MODIFICATIONS BASED ON TOXICITY LEVELS.

Renal Dosing

dialysis [CRCL >51-80 ml/min]: 
No changes to the starting dose.

[30-50]: 
A dose reduction to 75% of the XELODA starting dose when used as monotherapy or in combination with docetaxel (from 1250 mg/m2 to 950 mg/m2 twice daily) is recommended.

Subsequent dose adjustment is recommended as outlined in the package insert if a patient develops a grade 2 to 4 adverse event. SEE PACKAGE INSERT FOR DOSAGE MODIFICATIONS BASED ON TOXICITY LEVELS.

Hemodialysis

dialysis Specific guidelines not available.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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Capecitabine

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