Heparin Dosing Protocols- Affinity Health System

1. Obtain patient’s height and weight. Use actual body weight for all calculations
2. Obtain aPTT and INR prior to heparin therapy.
3. Obtain CBC prior to heparin therapy.
4. Loading Dose: [Options selected below]

• heparin 70 units/kg IV push for PE/DVT. (Maximum 10,000 units.)
• heparin 50 units/kg IV push for Afib/ACS not receiving fibrinolytics or GPIs (Maximum 5,000 units)
• heparin 50 units/kg IV push ACS with fibrinolytics or GPIs (Maximum 4,000 units)
• No bolus in stroke, impella, or provider request

5.Initial Maintenance Dose: Start heparin infusion (25,000 units/250 ml) using IV pump.
Begin immediately after loading dose. [Options selected below]

• 18 units/kg/hr PE/DVT (Maximum initial rate 2,000 units/hour.)
• 15 units/kg/hr Afib/ACS not receiving fibrinolytics or GPIs (Maximum initial rate 1,200 units/hour).
• 12 units/kg/hr Stroke/ACS receiving fibrinolytics or GPIs (Maximum initial rate 1,000 units/hour)
• 12 units/kg/hr Impella – Includes heparin from purge fluid, maximum initial infusion rate 1000 units/hr.

6. Obtain aPTT 8 hours after start of heparin infusion