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Common agents: bupivacaine, fentanyl, ropivacaine

Determine volume of epidural additives:
Volumes listed below assume a final volume of 250 ml.   If a volume other than 250ml is requested and any of the following additives are required (bupivacaine, fentanyl – alone or in combination), use our calculator

Using this chart:
Example order
Epidural:  0.125% bupivacaine with fentanyl concentration of 2 mcg/ml.
Using the table below, this would require 62.5 ml of bupivacaine and 10 ml of fentanyl for a total volume of 62.5 + 10 = 72.5ml.   Remove 72.5 ml from a 250 ml bag and then add the additives listed above for a total volume of 250 ml.

Bupivacaine 0.5% vials (preservative-free):
Desired concentration Volume needed
0.0625% 31.25 ml
0.075% 37.5 ml
0.1% 50 ml
0.125 % 62.5 ml
Bupivacaine 0.25% vials (preservative-free):
Desired concentration Volume needed
0.0625% 62.5 ml
0.075% 75 ml
0.1% 100 ml
0.125 % 125 ml
Ropivacaine 0.5% vials (preservative-free):
Desired concentration Volume needed
0.2% (preferred) 100ml
Ropivacaine 1.0% ampule (preservative-free):
Desired concentration Volume needed
0.2% (preferred) 50 ml
Fentanyl 50 mcg/ml  (preservative-free):
Desired concentration Volume needed
2 mcg/ml 10 ml
5 mcg/ml 25 ml
7.5 mcg/ml 37.5 ml
10 mcg/ml 50 ml
Hydromorphone 10 mg/ml  (preservative-free):
Look carefully at vial – many contain sodium metabisulfite which cannot be used.
Desired concentration Volume needed
25 mcg/ml 0.625 ml
50 mcg/ml 1.25 ml
75 mcg/ml 1.875 ml


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