| Initial U.S. Approval: 2015
Mechanism of Action: The mechanism of action of cariprazine in schizophrenia and bipolar I disorder is unknown. However, the efficacy of cariprazine could be mediated through a combination of partial agonist activity at central dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Cariprazine forms two major metabolites, desmethyl cariprazine (DCAR) and didesmethyl cariprazine (DDCAR), that have in vitro receptor binding profiles similar to the parent drug.
|INDICATIONS AND USAGE: VRAYLAR™ is indicated for the:
Treatment of schizophrenia.
Acute treatment of manic or mixed episodes associated with bipolar I disorder.
VRAYLAR (cariprazine) capsules are available in four strengths.
1.5 mg capsules: White cap and body imprinted with “FL 1.5”
National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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