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Drug Comparisons

Statins  (HMG-CoA Reductase Inhibitors)

' -- '  Signifies that equivalent tablet size is not available (comparable dose is either too high or too low)
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Equivalent Dosages -1

Atorvastatin (Lipitor ®):
-- (see tablet strengths)
Fluvastatin (Lescol ®): 
20 mg
Lovastatin (Mevacor ®):
10 mg
Pravastatin (Pravachol ®): 
10 mg
Rosuvastatin (Crestor ®): 
--
Simvastatin (Zocor ®):
5 mg

Equivalent Dosages - 2

Atorvastatin (Lipitor ®):
--
Fluvastatin (Lescol ®): 
40 mg
Lovastatin (Mevacor ®):
20 mg
Pravastatin (Pravachol ®): 
20 mg
Rosuvastatin (Crestor ®): 
--
Simvastatin (Zocor ®):
10 mg

Equivalent Dosages - 3

Atorvastatin (Lipitor ®):
10 mg
Fluvastatin (Lescol ®): 
80 mg
Lovastatin (Mevacor ®):
40 mg
Pravastatin (Pravachol ®): 
40 mg
Rosuvastatin (Crestor ®): 
5 mg
Simvastatin (Zocor ®):
20 mg

Equivalent Dosages - 4

Atorvastatin (Lipitor ®):
20 mg
Fluvastatin (Lescol ®): 
--
Lovastatin (Mevacor ®):
80 mg
Pravastatin (Pravachol ®): 
80 mg
Rosuvastatin (Crestor ®): 
5 - 10 mg
Simvastatin (Zocor ®):
40 mg

Equivalent Dosages - 5

Atorvastatin (Lipitor ®):
40 mg
Fluvastatin (Lescol ®): 
--
Lovastatin (Mevacor ®):
--
Pravastatin (Pravachol ®): 
--
Rosuvastatin (Crestor ®): 
10 - 20 mg
Simvastatin (Zocor ®):
80 mg

Atorvastatin (Lipitor ®)

Supplied:  10 mg, 20 mg, 40 mg, 80 mg
Dosing
Hyperlipidemias:  Adults:  Oral: Initial: 10-20 mg once daily.  Patients requiring >45% reduction in LDL-C may be started at 40 mg once daily.  Range: 10 to 80 mg once daily.
Adjustments should be made at intervals of 2-4 weeks.

Fluvastatin (Lescol ®)

Supplied:  Capsule: 20 mg, 40 mg.  Tablet, extended release (Lescol® XL): 80 mg
Dosing
Dyslipidemia: Oral: (Adults):  Patients requiring >/= 25% decrease in LDL-C: 40 mg capsule once daily in the evening, 80 mg XL tablet once daily (anytime), or 40 mg capsule twice daily.  Patients requiring <25% decrease in LDL-C: Initial: 20 mg capsule once daily in the evening; may increase based on tolerability and response to a maximum recommended dose of 80 mg/day, given in 2 divided doses (capsule) or as a single daily dose (XL tablet).

Lovastatin (Mevacor ®)

Supplied:  Tablet: 10 mg, 20 mg, 40 mgTablet, extended release: 20 mg, 40 mg, 60 mg
Dosing
Dyslipidemia: Oral:  (Adults): Initial: 20 mg with evening meal, then adjust at 4-week intervals; maximum: 80 mg/day immediate release tablet or 60 mg/day extended release tablet.Dosage modification/limits based on concurrent therapy:  Cyclosporine and other immunosuppressant drugs: Initial dose: 10 mg/day with a maximum recommended dose of 20 mg/day.
Concurrent therapy with fibrates, danazol, and/or lipid-lowering doses of niacin (>1 g/day): Maximum recommended dose: 20 mg/day. Concurrent use with fibrates should be avoided unless risk to benefit favors use.  Concurrent therapy with amiodarone or verapamil: Maximum recommended dose: 40 mg/day of regular release or 20 mg/day with extended release.

Pravastatin (Pravachol ®)

Supplied:  10 mg, 20 mg, 40 mg, 80 mg
Dosing
Hyperlipidemias: Oral:  (Adults): Initial: 40 mg once daily; titrate dosage to response (usual range: 10-80 mg) (maximum dose: 80 mg once daily).Dosage adjustment based on concomitant cyclosporine: Oral: Initial: 10 mg/day, titrate with caution (maximum dose: 20 mg/day).

Rosuvastatin (Crestor ®)

Supplied:  5 mg, 10 mg, 20 mg, 40 mg
Dosing
Hypercholesterolemia; mixed dyslipidemia: Oral: (Adults):  Initial dose: 10 mg once daily (20 mg in patients with severe hypercholesterolemia).   Conservative dosing: Patients requiring less aggressive treatment or predisposed to myopathy (including patients of Asian descent): 5 mg once daily.   Titration: After 2 weeks, may be increased by 5-10 mg once daily; dosing range: 5 to 40 mg/day (maximum dose: 40 mg once daily).
Dosage adjustment with concomitant medications: Oral: Cyclosporine: Rosuvastatin dose should not exceed 5 mg/day.  Gemfibrozil: Rosuvastatin dose should not exceed 10 mg/day.  Dosage adjustment for persistent, unexplained proteinuria while on 40 mg/day: Reduce dose and evaluate causes.

Simvastatin (Zocor ®)

Supplied:  5 mg, 10 mg, 20 mg, 40 mg, 80 mg
Dosing
:   Oral: (Adults):  Prevention of cardiovascular events, hyperlipidemias: Oral: 20-40 mg once daily in the evening; range: 5 to 80 mg/day.
Homozygous familial hypercholesterolemia: Oral: 40 mg once daily in the evening or 80 mg/day (given as 20 mg, 20 mg, and 40 mg evening dose).
Patients requiring only moderate reduction of LDL-cholesterol: May be started at 10 mg once daily
Patients requiring reduction of >45% in low-density lipoprotein (LDL) cholesterol: May be started at 40 mg once daily in the evening.  Patients with CHD or at high risk for CHD: Dosing should be started at 40 mg once daily in the evening; simvastatin may be started simultaneously with diet.Dosage adjustment for simvastatin with concomitant medications:  Cyclosporine or danazol: Patient must first demonstrate tolerance to simvastatin >/= 5 mg once daily: Initial: 5 mg, should not exceed 10 mg/day.  Fibrates or niacin: Dose should not exceed 10 mg/day. Amiodarone or verapamil: Dose should not exceed 20 mg/day.

References

Crestor (rosuvastatin) package insert. Wilmington, DE: AstraZeneca Pharmaceuticals LP; Aug 2003.
Drug Facts & Comparisons. St. Louis, MO. Facts & Comparisons. 2005.
Helfand, Mark, Carson, Susan, Kelley, Cathy. Drug Class Review on HMG-CoA Reductase Inhibitors (Statins). 2006. https://www.ohsu.edu/drugeffectiveness/reports/final.cfm  Accessed: Sept 2007.
Lescol (fluvastatin) package insert. East Hanover, NJ: Novartis Pharmaceuticals Corporation; October 2001.
Mevacor (lovastatin) package insert. West Point, PA: Merck & Co., Inc.; June 2002.
Lipitor (atorvastatin) package insert. Morris Plains, NJ: Parke-Davis; April 2002.
Pravachol (pravastatin) package insert. Princeton, NJ: Bristol-Myers Squibb; December 2001.
Zocor (simvastatin) package insert. Whitehouse Station, NJ: Merck & Co., Inc; May 2002.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

Statins (HMG-CoA Reductase Inhibitors)

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