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Wound infections  Possible therapeutic alternatives
Wound: Infected, post-op or trauma, without sepsis. (Not Gastrointestinal tract or female genital tract.) Common pathogens
Cephalexin 500mg orally 4 times daily or 
Duricef 1 gram orally once daily or cin 500mg po q12h or
Augmentin 500mg orally three times daily   or 
Dicloxacillin 500mg orally 4 times daily +/- Ciprofloxacin
Wound infection + sepsis. (does not include surgery involving GI or female genital tract) Common pathogens
Ampicillin-sulbactam 1.5 - 3 grams IV every 6 hours  or
Ticarcillin-clavulanic acid  3.1 grams  IV every 6 hours or  
Piperacillin-tazobactam 3.375 grams IV every 6 hours or 
Cefazolin 1 gram  IV every 8 hours.
Postop wound (surgery involving gastrointestinal tract or female genital tract)  (all regimens must cover anaerobes) Common pathogens
Cefotetan 2 grams ivpb q12h or   or 
Cefoxitin 1 gram IV every 6 hours or
Ticarcillin-clavulanic acid  3.1grams IV every 6 hours  or 
Ampicillin-sulbactam 1.5-3g ivpb q6h or  
[ (Cefotaxime 1g ivpb q8h or Ceftriaxone1-2g ivpb q24h ) +  Metronidazole 500mg ivpb q6-8h]  or
Imipenem 500mg ivpb q6h.


 

 


References

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Bartlett JG.1998 Pocket Book of Infectious Disease Therapy., Ninth Edition. Baltimore,MD: Williams&Wikins,1998.
Bernstein JM: Treatment of community-acquired pneumonia--IDSA guidelines. Infectious Diseases Society of America. Chest 1999 Mar; 115(3 Suppl): 9S-13S
Drug Information Handbook, 5th Ed. 1997, Lexi-Comp inc. 
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Gonzales R, Sande M: What will it take to stop physicians from prescribing antibiotics in acute bronchitis? Lancet 1995 Mar 18; 345(8951): 665-6
Hooton TM, Stamm WE. Diagnosis and treatment of uncomplicated urinary tract infection. Infect Dis Clin North Am 1997;11:551-581.
Lipsky BA, Berendt AR.Principles and practice of antibiotic therapy of diabetic foot infections.
Diabetes Metab Res Rev. 2000 Sep-Oct;16 Suppl 1:S42-6.
Mufson MA.Pneumococcal Pneumonia.
Curr Infect Dis Rep. 1999 Apr;1(1):57-64.
Reese RE, Betts RF: A Practical Approach to Infectious Diseases. 4th ed. Boston: Little, Brown, and Company; 1996: 251
Stefani SD, Cadore LP, Villaroel RU, Azevedo S, Machado AL. Antibiotic Selection in the Treatment of Febrile Neutropenia: Current Approach and New Directions.
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