| Tuberculosis - therapeutic agents |
| Ethambutol |
Dosing: 15-25 mg/kg up to 2500 mg orally once daily. |
| Isoniazid |
Adults: 5mg/kg/day PO (maximum 300mg);or 15mg/kg (maximum 900mg) 2-3 times weekly. |
| Pyrazinamide |
Adults: 15 to 30 mg/kg/day (maximum of 2 grams daily). Alternative regimen: 50 to 70 mg/kg two or three times weekly (maximum 3 grams/dose). |
| rifabutin (Mycobutin): |
300 mg orally once daily or 150 mg orally twice a day given with a meal. |
| Rifamate (INH 150mg + rifampin 300mg): |
Take 2 capsules orally once daily 1 hour before or 2 hours after a meal. (2 capsules = 600 mg rifampin, 300 mg isoniazid) |
| Rifampin |
TB: 10-20 mg/kg up to 600 mg oral or IV once daily.
Synergy gram (+): (900-1200 mg/day in 3 divided doses): Usual dose: 300 mg orally every 8 hours. Some recommend 600 mg orally once daily. |
| rifapentine (Priftin): |
Cyclopentyl derivative of rifampin (longer duration of action and greater efficacy compared to rifampin). Dosing: 600 mg orally twice weekly x 2 months, then once weekly x 4 months. (Twice weekly if HIV). |
| Rifater ( INH50mg+rif 120mg +pyr300mg): |
Dosing: 6 tabs orally once daily (if > 55kg). 5 tabs orally once daily if < 55 kg. (Take 1 hour before or 2 hours after a meal with a full glass of water.) |
