(IV): 500mg to 2 grams IV q4-6h.
[Severe infection]: 2 grams IV q4h (150-200mg/kg/day).
(Oral): 250mg to 500mg orally q6h (50-100mg/kg/ day).
DOSAGE AND ADMINISTRATION
ADULTS AND CHILDREN WEIGHING OVER 20 KG:
For genitourinary or gastrointestinal tract infections other than gonorrhea in
men and women, the usual dose is 500 mg qid in equally spaced doses; severe or
chronic infections may require larger doses. For the treatment of gonorrhea in
both men and women, a single oral dose of 3.5 grams of ampicillin administered
simultaneously with 1 gram of probenecid is recommended. Physicians are
cautioned to use no less than the above recommended dosage for the treatment of
gonorrhea. Follow-up cultures should be obtained from the original site(s) of
infection 7 to 14 days after therapy. In women, it is also desirable to obtain
culture test-of-cure from both the endocervical and anal canals. Prolonged
intensive therapy is needed for complications such as prostatitis and
For respiratory tract infections, the usual dose is 250 mg qid in equally spaced
CHILDREN WEIGHING 20 KG OR LESS:
For genitourinary or gastrointestinal tract infections, the usual dose is 100
mg/kg/day total, qid in equally divided and spaced doses. For respiratory
infections, the usual dose is 50 mg/kg/day total, in equally divided and spaced
doses three to four times daily. Doses for children should not exceed doses
recommended for adults.
ALL PATIENTS, IRRESPECTIVE OF AGE AND WEIGHT:
Larger doses may be required for severe or chronic infections. Although
ampicillin is resistant to degradation by gastric acid, it should be
administered at least one-half hour before or two hours after meals for maximal
absorption. Except for the single dose regimen for gonorrhea referred to above,
therapy should be continued for a minimum of 48 to 72 hours after the patient
becomes asymptomatic or evidence of bacterial eradication has been obtained. In
infections caused by hemolytic strains of streptococci, a minimum of 10 days’
treatment is recommended to guard against the risk of rheumatic fever of
glomerulonephritis. In the treatment of chronic urinary or
gastrointestinal infections, frequent bacteriologic and clinical appraisal is
necessary during therapy and may be necessary for several months afterwards.
Stubborn infections may require treatment for several weeks. Smaller doses than
those indicated above should not be used.
Oral / IV:
[CRCL >50]: no change.
[30-49 ml/min]: q6-8 hours.
[10-29 ml/min]: q8-12 hours.
[<10 ml/min]: q12-24 hours.
[<10 ml/min]: Give usual dose every 12-24 hours. Schedule dose after
dialysis on dialysis days.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
judgment. Neither GlobalRPh Inc. nor any other party involved in the
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