Naltrexone / bupropion - CONTRAVE ER tablets | GlobalRPh Renal Dosing Master

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1 additional source qualifications - review before use

CONTRAVE: a maximum does not replace titration

The qualitative renal ceiling belongs to a fixed combination. Parent-drug PK does not negate increased metabolite exposure.

Before applying: Do not invent numeric renal bands or apply this ceiling to naltrexone alone.

Also check: CONTRAVE: a maximum does not replace titration

Rxlist source

GlobalRPh RX List - CONTRAVE

Product / population: Naltrexone / bupropion - CONTRAVE ER tablets; selected source sections, not a full prescribing monograph.
Renal measure: Qualitative renal statement; no numeric renal algorithm inferred.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

For moderate or severe renal impairment, the maximum is two tablets per day: one each morning and evening. Each ER tablet contains naltrexone hydrochloride 8 mg and bupropion hydrochloride 90 mg. ESRD use is not recommended. This ceiling does not replace initial titration. The renal passage gives qualitative categories, not numerical clearance cutoffs. Although parent-drug pharmacokinetics were not significantly changed, metabolites had increased exposure. Do not transfer this combination schedule to either ingredient alone.

Source revision: RX page prints May 2024. | Retrieved: 2026-09-08. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/contrave-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Evidence sources and renal implications

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Read 1 source difference / applicability notes

GlobalRPh RX List

GlobalRPh RX List - CONTRAVE

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Naltrexone / bupropion - CONTRAVE ER tablets; selected source sections, not a full prescribing monograph.

Renal method: Qualitative renal statement; no numeric renal algorithm inferred.
Retrieved: 2026-09-08

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Source-specific review points

CONTRAVE: a maximum does not replace titration

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Jump to renal guidance Read 1 difference / caution notes Clinician guide

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Population Kidney-function trend Renal replacement setting

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See source-specific renal methods and the clinical interpretation guide for the supporting context.

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Source differences and product cautions

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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

formulation scope

CONTRAVE: a maximum does not replace titration

The qualitative renal ceiling belongs to a fixed combination. Parent-drug PK does not negate increased metabolite exposure.

How to use this: Do not invent numeric renal bands or apply this ceiling to naltrexone alone.

GlobalRPh RX List - CONTRAVE Naltrexone - VIVITROL extended-release injection

Source-specific interpretation; independent clinician adjudication pending.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

Rxlist source

GlobalRPh RX List - CONTRAVE

Naltrexone / bupropion - CONTRAVE ER tablets; selected source sections, not a full prescribing monograph.

Method: Qualitative renal statement; no numeric renal algorithm inferred.

Renal dosing, restrictions and evidence limits Read this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scope GlobalRPh RX List - CONTRAVE

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/contrave-drug/

Exact product and population

Naltrexone / bupropion - CONTRAVE ER tablets; selected source sections, not a full prescribing monograph.

RDM48-SCOPE-naltrexone-bupropion-contrave · Source section: Selected source product scopeRenal section finder

Locally imported selected renal sections

GlobalRPh RX List renal information

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GlobalRPh RX List - CONTRAVE

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GlobalRPh-hosted RX List · Naltrexone / bupropion - CONTRAVE ER tablets; selected source sections, not a full prescribing monograph.

Renal method: Qualitative renal statement; no numeric renal algorithm inferred.
Source date: RX page prints May 2024.
Retrieved: 2026-09-08

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

RDM48-rxlist-naltrexone-bupropion-contrave-fa83f0edf4-C1 · Source locator: Description; renal dosage; Use in Specific Populations: renal impairment; renal pharmacokinetics.

Source identity and provenance

Source family: product_label_mirror
Source: https://globalrph.com/rx-list/contrave-drug/
Retrieved: 2026-09-08
Renal-function method: Qualitative renal statement; no numeric renal algorithm inferred.
Source date/version: RX page prints May 2024.
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: bdc21258639ae8a9e89854596590e6d9fd2291908a85b43cc5709b204079d471

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/rx-list/contrave-drug/
Source retrieval: 2026-09-08. This is not the source publication or label revision date.
Original source type: rxlist summary
Local text SHA-256: ae605d61014ccae53ec902b9aa32afd9ea0bd60c63849046c082088a22c70deb
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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