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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.
1 additional source qualifications - review before use
Severe-impairment maintenance and switching instructions specify both the prior immediate-release regimen and the XR product.
Before applying: Confirm Cockcroft-Gault clearance, release form and the established dose; avoid milligram-for-milligram substitution.
Also check: NAMENDA XR: renal maintenance and release-form conversion
Official source
Memantine - extended-release capsules
Product / population
Adults with moderate-to-severe Alzheimer-type dementia; exact release formulation.
Renal measure
Cockcroft-Gault creatinine clearance, mL/min.
Renal guidance and important limits
Limits that apply to these rows
These are maintenance limits, not initial titration doses. Do not extrapolate below CrCl 5 or create a dialysis replacement regimen.
Alkaline urine can reduce elimination. Reinitiation after several missed days may require retitration. Fixed memantine/donepezil is a separate product.
Memantine ER - renal maintenance maximum
Cockcroft-Gault CrCl (mL/min)
Source-specific instruction
5-29
Recommended maintenance and maximum: 14 mg once daily
Mild/moderate renal impairment
No renal adjustment needed
Read the retained text before reformatting
Memantine ER - renal maintenance maximum
Cockcroft-Gault CrCl (mL/min)
Source-specific instruction
5-29
Recommended maintenance and maximum: 14 mg once daily
Mild/moderate renal impairment
No renal adjustment needed
These are maintenance limits, not initial titration doses. Do not extrapolate below CrCl 5 or create a dialysis replacement regimen.
Alkaline urine can reduce elimination. Reinitiation after several missed days may require retitration. Fixed memantine/donepezil is a separate product.
Source revision: 4/2025 | Retrieved: 2026-09-10. Retrieval date is not the revision date.
All sources, comparison tools and evidence navigation
Source-first renal review
Evidence sources and renal implications
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Renal-context checklist: population, kidney trend and dialysis
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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.
formulation scope
NAMENDA XR: renal maintenance and release-form conversion
Severe-impairment maintenance and switching instructions specify both the prior immediate-release regimen and the XR product.
How to use this: Confirm Cockcroft-Gault clearance, release form and the established dose; avoid milligram-for-milligram substitution.
Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.
New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.
Official source
Memantine - extended-release capsules
Adults with moderate-to-severe Alzheimer-type dementia; exact release formulation.
No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.
Compare or copy source versions
All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding
Confirm IR, ER or fixed combination; keep the maintenance limit separate from titration and restart instructions.
Selected source sections stored locally. Not a complete monograph or independent clinical approval.
Renal guidance and important limits
Limits that apply to these rows
These are maintenance limits, not initial titration doses. Do not extrapolate below CrCl 5 or create a dialysis replacement regimen.
Alkaline urine can reduce elimination. Reinitiation after several missed days may require retitration. Fixed memantine/donepezil is a separate product.
Memantine ER - renal maintenance maximum
Cockcroft-Gault CrCl (mL/min)
Source-specific instruction
5-29
Recommended maintenance and maximum: 14 mg once daily
Mild/moderate renal impairment
No renal adjustment needed
Read the retained text before reformatting
Memantine ER - renal maintenance maximum
Cockcroft-Gault CrCl (mL/min)
Source-specific instruction
5-29
Recommended maintenance and maximum: 14 mg once daily
Mild/moderate renal impairment
No renal adjustment needed
These are maintenance limits, not initial titration doses. Do not extrapolate below CrCl 5 or create a dialysis replacement regimen.
Alkaline urine can reduce elimination. Reinitiation after several missed days may require retitration. Fixed memantine/donepezil is a separate product.
These are maintenance limits, not initial titration doses. Do not extrapolate below CrCl 5 or create a dialysis replacement regimen.
Alkaline urine can reduce elimination. Reinitiation after several missed days may require retitration. Fixed memantine/donepezil is a separate product.
GlobalRPh-hosted RX List · Memantine - NAMENDA XR capsules; selected source sections, not a full prescribing monograph.
Renal method: Cockcroft-Gault creatinine clearance (CrCl), mL/min. Source date: RX page prints November 2019. Retrieved: 2026-09-08
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
For severe impairment, Cockcroft-Gault CrCl 5-29 mL/min, recommended maintenance and maximum dosage is 14 mg once daily. No adjustment is recommended for mild or moderate impairment. A patient with severe impairment taking immediate-release memantine 5 mg twice daily may switch to XR 14 mg once daily on the day after the final immediate-release dose. Keep release form and prior regimen explicit; this is not a milligram-for-milligram conversion or a dialysis recommendation.
RDM48-rxlist-memantine-namenda-xr-a6643f52d3-C1 · Source locator: Switching instructions and renal dosage; Use in Specific Populations: renal impairment.
Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.
This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.