GlobalRPh RX List - NAMZARIC
- Product / population
- Memantine ER / donepezil - NAMZARIC capsules; selected source sections, not a full prescribing monograph.
- Renal measure
- Cockcroft-Gault creatinine clearance (CrCl), mL/min.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
With severe impairment (Cockcroft-Gault CrCl 5-29 mL/min) and established donepezil 10 mg daily, start NAMZARIC 7 mg/10 mg each evening, increasing after at least one week to 14 mg/10 mg each evening. Patients already stabilized on memantine 5 mg twice daily or XR 14 mg daily plus donepezil 10 mg daily may switch to NAMZARIC 14 mg/10 mg each evening. Mild or moderate impairment requires no adjustment. The two-component schedule depends on the established regimen; it is not memantine monotherapy dosing.