GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Itraconazole

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Renal measure
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The renal statement is specifically about oral itraconazole. It must not be generalized to the source IV formulation or its excipients.

Usual Dosing (Adults)

Capsules should be taken with a full meal for maximal absorption. Capsules and oral solution are different preparations and must not be used interchangeably. Only solution has demonstrated effectiveness for oral/esophageal candidiasis.

Blastomycosis/histoplasmosis: 200 mg daily (two capsules); if no improvement or progressive disease, increase by 100 mg up to 400 mg/day. Divide daily doses above 200 mg in two. Aspergillosis: 200 to 400 mg/day.

Life-threatening situations: loading recommended for capsules or IV. Source IV regimen: 200 mg twice daily for four doses, then 200 mg daily, each over 1 hour; safety/efficacy beyond 14 IV days unknown. Capsule PK-based loading: 200 mg three times daily for the first 3 days, although trials did not include a loading dose. Continue at least 3 months and until clinical/laboratory disease subsides; inadequate duration can cause recurrence.

Toenail onychomycosis with/without fingernails: 200 mg daily for 12 weeks. Fingernails only: two pulses of 200 mg twice daily for 1 week each, separated by 3 weeks off therapy.

Renal Dosing

Limited data on oral itraconazole in renal impairment. Exercise caution.

Hemodialysis

See the renal impairment caution above.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/itraconazole/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Important source distinctions

The renal statement is specifically about oral itraconazole. It must not be generalized to the source IV formulation or its excipients.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/itraconazole/

Usual Dosing (Adults)

Capsules should be taken with a full meal for maximal absorption. Capsules and oral solution are different preparations and must not be used interchangeably. Only solution has demonstrated effectiveness for oral/esophageal candidiasis.

Blastomycosis/histoplasmosis: 200 mg daily (two capsules); if no improvement or progressive disease, increase by 100 mg up to 400 mg/day. Divide daily doses above 200 mg in two. Aspergillosis: 200 to 400 mg/day.

Life-threatening situations: loading recommended for capsules or IV. Source IV regimen: 200 mg twice daily for four doses, then 200 mg daily, each over 1 hour; safety/efficacy beyond 14 IV days unknown. Capsule PK-based loading: 200 mg three times daily for the first 3 days, although trials did not include a loading dose. Continue at least 3 months and until clinical/laboratory disease subsides; inadequate duration can cause recurrence.

Toenail onychomycosis with/without fingernails: 200 mg daily for 12 weeks. Fingernails only: two pulses of 200 mg twice daily for 1 week each, separated by 3 weeks off therapy.

GRPH-itraconazole-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Limited data on oral itraconazole in renal impairment. Exercise caution.

GRPH-itraconazole-02 · Source section: Renal DosingRenal section finder

Hemodialysis

See the renal impairment caution above.

GRPH-itraconazole-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/itraconazole/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
28784bc276b1eb362ff61028968832012cf4cea798b9a819538a3c79dfaba49e
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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