Hydroxyurea scored tablets - SIKLOS | GlobalRPh Renal Dosing Master

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The same 50% renal reduction starts from different adult and pediatric doses

SIKLOS provides separate pediatric and adult starting doses. The DROXIA extract is adult capsule guidance. Applying the adult starting amount to a child would change the regimen even if the percentage reduction were correct.

Before applying: Use the exact age/product starting dose, prescribed weight method, measured CrCl instruction and hematology monitoring plan. Related hydroxyurea products remain separate.

Also check: The same 50% renal reduction starts from different adult and pediatric doses

Official source

Hydroxyurea scored tablets - SIKLOS

Product / population: SIKLOS hydroxyurea 100-mg and 1000-mg scored tablets; sickle cell anemia, age >=2 years
Renal measure: CrCl, mL/min, obtained using a 24-hour urine collection

Renal dosing, restrictions and evidence limits

At CrCl >=60 mL/min, the initial daily dose is 20 mg/kg in pediatric patients and 15 mg/kg in adults. Below 60 or in ESRD, reduce by 50%: 10 mg/kg/day in children and 7.5 mg/kg/day in adults. Obtain CrCl using a 24-hour urine collection. On hemodialysis days, administer after dialysis.

For starting-dose weight, use actual or ideal body weight, whichever is less. Monitor blood counts every two weeks and follow the full escalation, toxicity interruption and recovery instructions. These scored tablets are labeled for sickle cell anemia in adults and children at least two years old; do not substitute the adult DROXIA capsule starting dose for the pediatric SIKLOS dose.

Source revision: November 2023 | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=76957c0d-0f98-4376-bb06-eee651adc09d

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Hydroxyurea scored tablets - SIKLOS

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SIKLOS hydroxyurea 100-mg and 1000-mg scored tablets; sickle cell anemia, age >=2 years

Renal method: CrCl, mL/min, obtained using a 24-hour urine collection
Retrieved: 2026-09-07

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The same 50% renal reduction starts from different adult and pediatric doses

How to use this: Use the exact age/product starting dose, prescribed weight method, measured CrCl instruction and hematology monitoring plan. Related hydroxyurea products remain separate.

Hydroxyurea scored tablets - SIKLOS Hydroxyurea capsules for sickle cell anemia - DROXIA Hydroxyurea capsules (Hydrea, oncology)

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Official source

Hydroxyurea scored tablets - SIKLOS

SIKLOS hydroxyurea 100-mg and 1000-mg scored tablets; sickle cell anemia, age >=2 years

Method: CrCl, mL/min, obtained using a 24-hour urine collection

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Original content / product scope Hydroxyurea scored tablets - SIKLOS

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SIKLOS hydroxyurea 100-mg and 1000-mg scored tablets; sickle cell anemia, age >=2 years

RDM38-SCOPE-hydroxyurea-siklos · Source section: Selected source product scopeRenal section finder

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Hydroxyurea scored tablets - SIKLOS

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DailyMed / Medunik USA · SIKLOS hydroxyurea 100-mg and 1000-mg scored tablets; sickle cell anemia, age >=2 years

Renal method: CrCl, mL/min, obtained using a 24-hour urine collection
Source date: November 2023
Retrieved: 2026-09-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

RDM38-official-hydroxyurea-siklos-20ae06ae5f-C1 · Source locator: Sections 1, 2.1, 2.2 renal table and 5.1

Source identity and provenance

Source family: product_label
Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=76957c0d-0f98-4376-bb06-eee651adc09d
Retrieved: 2026-09-07
Exact label title: Hydroxyurea scored tablets - SIKLOS
DailyMed Set ID: 76957c0d-0f98-4376-bb06-eee651adc09d
Labeler: Medunik USA
Label revision: November 2023
Renal-function method: CrCl, mL/min, obtained using a 24-hour urine collection
Source date/version: November 2023
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: 316f07d515ddc354bd2a13c4156f70103171a19b458af4c48453f08a6a1c0c23

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=76957c0d-0f98-4376-bb06-eee651adc09d
Source retrieval: 2026-09-07. This is not the source publication or label revision date.
Original source type: source summary
Local text SHA-256: 588702d3487b1a354f582210bbbc0297096e5239129e46771cdc64422dd5a6db
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This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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