GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Hydroxyurea capsules for sickle cell anemia - DROXIA

Local RX List renal extractBase record retrieved 2026-09-07See the evidence for this drug1 sources available - open source summaries, references and comparisons

DROXIA

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Rxlist source

GlobalRPh RX List - DROXIA

Product / population
Adult DROXIA capsules for sickle cell anemia; not an all-product hydroxyurea regimen
Renal measure
CrCl, mL/min; source renal data used 24-hour urine collection

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

Initial adult dose: CrCl >=60 mL/min, 15 mg/kg once daily; CrCl <60 or ESRD, 7.5 mg/kg once daily, a 50% reduction. Use actual or ideal body weight, whichever is lower. On dialysis days, give the dose after hemodialysis. The source states that the renal study used 24-hour urine creatinine clearance.

Monitor blood counts closely, with the source recommending every two weeks; subsequent escalation and toxicity interruptions require the full hematology protocol. Hydroxyurea can interfere with urea/uric acid assays and some continuous glucose sensors. Do not apply the adult starting dose automatically to pediatric sickle cell treatment or other hydroxyurea products.

Source revision: November 2023 | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/droxia-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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GlobalRPh RX List

GlobalRPh RX List - DROXIA

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult DROXIA capsules for sickle cell anemia; not an all-product hydroxyurea regimen

Renal method: CrCl, mL/min; source renal data used 24-hour urine collection
Retrieved: 2026-09-07

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Original content / product scopeGlobalRPh RX List - DROXIA
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/droxia-drug/

Exact product and population

Adult DROXIA capsules for sickle cell anemia; not an all-product hydroxyurea regimen

RDM38-SCOPE-hydroxyurea-droxia · Source section: Selected source product scopeRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

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GlobalRPh RX List - DROXIA

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GlobalRPh-hosted RX List · Adult DROXIA capsules for sickle cell anemia; not an all-product hydroxyurea regimen

Renal method: CrCl, mL/min; source renal data used 24-hour urine collection
Source date: November 2023
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Initial adult dose: CrCl >=60 mL/min, 15 mg/kg once daily; CrCl <60 or ESRD, 7.5 mg/kg once daily, a 50% reduction. Use actual or ideal body weight, whichever is lower. On dialysis days, give the dose after hemodialysis. The source states that the renal study used 24-hour urine creatinine clearance.

Monitor blood counts closely, with the source recommending every two weeks; subsequent escalation and toxicity interruptions require the full hematology protocol. Hydroxyurea can interfere with urea/uric acid assays and some continuous glucose sensors. Do not apply the adult starting dose automatically to pediatric sickle cell treatment or other hydroxyurea products.

RDM38-rxlist-hydroxyurea-droxia-b38aba4b69-C1 · Source locator: Dose modifications for renal impairment; table 1; laboratory interference

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/droxia-drug/
Retrieved
2026-09-07
Renal-function method
CrCl, mL/min; source renal data used 24-hour urine collection
Source date/version
November 2023
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
cd2ef169df68120a474679fc477d1b5fed9b111195512eb67273d6afccbed538

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/droxia-drug/
Source retrieval
2026-09-07. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
ebf785f36d9e325a5a255fc583f4a019543a0067eaf1d6d16c43f3eb9be3d4d6
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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