Hydroxyurea capsules (Hydrea, oncology) | GlobalRPh Renal Dosing Master

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Official source

Hydroxyurea capsules (Hydrea, oncology) - selected U.S. label sections

Product / population: HYDREA oncology capsules only. Not a SIKLOS or DROXIA sickle-cell dosing protocol.
Renal measure: Creatinine clearance in mL/min

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Initial renal dosing

CrCl	Initial oral dose
60 mL/min or higher	15 mg/kg once daily
Below 60 mL/min or ESRD	7.5 mg/kg once daily

This is a 50% initial-dose reduction. On hemodialysis days, give the dose after dialysis.

Monitoring and scope

Monitor hematologic parameters closely and adjust treatment for marrow suppression. The renal table does not replace indication-specific duration, weight selection or subsequent toxicity adjustments in the full label.

Source revision: Revision not captured; retrieval date is not the revision date. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6053c775-68de-45e4-9af9-33b18fd0e140

Scope: Local label summary; independent clinical review pending. Not a two-source validated protocol. GlobalRPh v6.6.

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Evidence sources and renal implications

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Official product label

Hydroxyurea capsules (Hydrea, oncology) - selected U.S. label sections

HYDREA oncology capsules only. Not a SIKLOS or DROXIA sickle-cell dosing protocol.

Renal method: Creatinine clearance in mL/min
Retrieved: 2026-09-05

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

Official source

Hydroxyurea capsules (Hydrea, oncology) - selected U.S. label sections

HYDREA oncology capsules only. Not a SIKLOS or DROXIA sickle-cell dosing protocol.

Method: Creatinine clearance in mL/min

Initial renal dosing Read this complete source summary

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Original content / product scope Hydroxyurea capsules (Hydrea, oncology) - selected U.S. label sections

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6053c775-68de-45e4-9af9-33b18fd0e140

Product and population scope

HYDREA oncology capsules only. Not a SIKLOS or DROXIA sickle-cell dosing protocol.

RDM32-hydroxyurea-hydrea-scope · Source section: Editorial scope for the selected U.S. labelRenal section finder

Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

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Hydroxyurea capsules (Hydrea, oncology) - selected U.S. label sections

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U.S. product labeling / DailyMed · HYDREA oncology capsules only. Not a SIKLOS or DROXIA sickle-cell dosing protocol.

Renal method: Creatinine clearance in mL/min
Source date: Revision not captured; retrieval date is not the revision date.
Retrieved: 2026-09-05

Local label summary; independent clinical review pending. Not a two-source validated protocol.

Initial renal dosing

CrCl	Initial oral dose
60 mL/min or higher	15 mg/kg once daily
Below 60 mL/min or ESRD	7.5 mg/kg once daily

This is a 50% initial-dose reduction. On hemodialysis days, give the dose after dialysis.

RDM32-hydroxyurea-hydrea-1 · Source locator: 2.3; 8.6

Monitoring and scope

RDM32-hydroxyurea-hydrea-2 · Source locator: 2; 5.1; 8.6

Source-specific limits

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Source identity and provenance

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6053c775-68de-45e4-9af9-33b18fd0e140
Retrieved: 2026-09-05
DailyMed Set ID: 6053c775-68de-45e4-9af9-33b18fd0e140
Renal-function method: Creatinine clearance in mL/min
Source date/version: Revision not captured; retrieval date is not the revision date.
Hash meaning: SHA-256 identifies this local summary, not original SPL XML or a label PDF.
Local summary SHA-256: 58d28528151640127c107cb2b125c6e34fffcea43bf92bdff61c77332d858822

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6053c775-68de-45e4-9af9-33b18fd0e140
Source retrieval: 2026-09-05. This is not the source publication or label revision date.
Original source type: multisource addition
Local text SHA-256: ed688044ccaf7f8e99a8ceade6bafb5bac296388b30a893a425292f2f02cab3f
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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