GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Amoxicillin/Clav

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons
READ THE SOURCE-SPECIFIC ANSWER

Renal guidance at a glance

Cautions / source differences (1)
Review first - source-specific qualification

Conventional AUGMENTIN is not XR or ES-600

The conventional renal table cannot be transferred to XR, and clavulanate content differs among formulations.

Before applying: Match both component strengths and formulation before using any table.

Evidence for this qualification

Source-specific interpretation; independent clinician adjudication pending.

Confirm the product, indication and renal measure. The selected summary is not a complete prescribing monograph.

Choose a source to read (3)

Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

Rxlist source

GlobalRPh RX List - AUGMENTIN

Product / population
Conventional AUGMENTIN adult renal paragraph; not extended-release or ES-600.
Renal measure
GFR (mL/min), as printed

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Before using this finding

Match both component strengths and formulation; compare dialysis instructions as a whole protocol.

No new official-label card was obtained for this product in v6.1. Earlier source layers, if present, were retained but not rechecked.

Renal guidance and important limits

The selected conventional-product renal paragraph excludes the 875 mg dose when GFR is below 30 mL/min.

GFR / treatmentSelected dose expressed by amoxicillin component
10-30 mL/min250 or 500 mg every 12 hours, according to infection severity
Below 10 mL/min250 or 500 mg every 24 hours, according to infection severity
Hemodialysis250 or 500 mg every 24 hours; additional dose both during and at the end of dialysis

The adult 250 mg tablet and 250 mg chewable tablet have different clavulanate amounts. These instructions are not an AUGMENTIN XR or ES-600 conversion. Confirm the complete component strength, not amoxicillin milligrams alone.

Source revision: Revision not established in selected retrieval | Retrieved: 2026-09-10. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/augmentin-drug/

Scope: Selected source sections stored locally. Not a complete monograph or independent clinical approval. GlobalRPh v6.6.

Full source card / provenance

All sources, comparison tools and evidence navigation
Source-specific interpretation

What the dialysis evidence actually supports

Removal information alone does not define a maintenance dose, supplemental dose or dialysis schedule. A reported regimen still requires its product, indication, renal measure and dialysis assumptions to match the patient.

GlobalRPh RX List - AUGMENTIN

Authored v6.1; retrieved 2026-09-10 - retained source, not freshly reviewed in this release

A regimen is reported in selected content

Read the source and its limits

These manual classifications apply only to the identified selected sections, not every retained source or the entire prescribing information. They are not dosing clearance.

Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 1 source difference / applicability notes

Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
GlobalRPh RX List

GlobalRPh RX List - AUGMENTIN

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Match both component strengths and formulation; compare dialysis instructions as a whole protocol.

Dialysis evidence: A regimen is reported in selected content

Conventional AUGMENTIN adult renal paragraph; not extended-release or ES-600.

Renal method: GFR (mL/min), as printed
Retrieved: 2026-09-10

Read local renal resultOpen original reference
Professional guidance

UCSF - amoxicillin/clavulanate: standard and bloodstream-infection regimens

Adults; oral immediate-release amoxicillin/clavulanate. Separate indication-specific institutional schedules.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Product / population check

Confirm the exact formulation before using a renal source

These links compare product identities, not interchangeable doses. A selected summary is not a complete prescribing monograph.

Source-quality holds
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Find a term without leaving this drug

Search the stored clinical text

Locate a word or phrase within this drug's source summaries. Choose all sources or one source to focus the search. The selection never hides warnings or source text, changes a dose, or proves that a renal finding is absent.

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All source summaries, original wording and provenance
Before applying a renal protocol

Check the setting. Compare whole sources.

No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.

Share a reproducible source review

Choose sources below, then open a print-ready comparison with product scope, renal method, dates and cautions. Links can pin the exact local cards; they never contain patient values or choose a dose.

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Jump to renal guidanceRead 1 difference / caution notesClinician guide

Select two distinct source versions. The complete stored summaries will appear below.

Build a source-review outline for documentation

This creates a blank decision outline with the source identities you select, not a dose recommendation or completed clinical assessment. No patient fields are collected, saved or sent. Complete the clinical decisions in your approved documentation system.

Choose one or two sources above or use the source checkboxes below.

Renal-context checklist: population, kidney trend and dialysis

These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.

Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.

See source-specific renal methods and the clinical interpretation guide for the supporting context.

Read before choosing a regimen

Source differences and product cautions

Search differences across all drugs

These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

Go directly to the relevant source section

Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeGlobalRPh RX List - AUGMENTINUCSF - amoxicillin/clavulanate: standard and bloodstream-infection regimens
Choose two source checkboxes below.
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

The source summary mentions an after-dialysis dose; the source package-insert paragraph says both during and at the end of dialysis. Both statements are retained and require product-specific reconciliation.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/amoxicillinclav/

Usual Dosing (Adults)

DOSAGE AND ADMINISTRATION

Since both the 250-mg and 500-mg tablets of AUGMENTIN contain the same amount of clavulanic acid (125 mg, as the potassium salt), two 250-mg tablets of AUGMENTIN are not equivalent to one 500-mg tablet of AUGMENTIN; therefore, two 250-mg tablets of AUGMENTIN should not be substituted for one 500-mg tablet of AUGMENTIN.

Dosage - Adults

The usual adult dose is one 500-mg tablet of AUGMENTIN every 12 hours or one 250-mg tablet of AUGMENTIN every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 875-mg tablet of AUGMENTIN every 12 hours or one 500-mg tablet of AUGMENTIN every 8 hours.

Pediatric Patients

Pediatric patients weighing 40 kg or more should be dosed according to the adult recommendations. Due to the different amoxicillin to clavulanic acid ratios in the 250-mg tablet of AUGMENTIN (250/125) versus the 250-mg chewable tablet of AUGMENTIN (250/62.5), the 250-mg tablet of AUGMENTIN should not be used until the pediatric patient weighs at least 40 kg or more.

Administration

AUGMENTIN may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when AUGMENTIN is administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, AUGMENTIN should be taken at the start of a meal.

GRPH-amoxicillinclav-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

PO:

[CRCL >30]: no change

[10-30]: 250-500 mg q12h. Do not use the 875 mg tablet.

[<10 ml/min]: 250-500 mg q24h. Do not use the 875 mg tablet.

Package insert: Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe. Severely impaired patients with a glomerular filtration rate of <30 mL/min should not receive the 875-mg tablet. Patients with a glomerular filtration rate of 10 to 30 mL/min should receive 500 mg or 250 mg every 12 hours, depending on the severity of the infection. Patients with a less than 10 mL/min glomerular filtration rate should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection.

GRPH-amoxicillinclav-02 · Source section: Renal DosingRenal section finder

Hemodialysis

250/125 to 500/125mg q24h. Give additional dose after dialysis.

Package insert: Hemodialysis patients should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis.

GRPH-amoxicillinclav-03 · Source section: HemodialysisRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - AUGMENTIN

Open original reference

Open / share this exact local source

GlobalRPh-hosted RX List · Conventional AUGMENTIN adult renal paragraph; not extended-release or ES-600.

Renal method: GFR (mL/min), as printed
Source date: Revision not established in selected retrieval
Retrieved: 2026-09-10

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Match both component strengths and formulation; compare dialysis instructions as a whole protocol.

Dialysis evidence: A regimen is reported in selected content

Selected source sections stored locally. Not a complete monograph or independent clinical approval.

Renal guidance and important limits

The selected conventional-product renal paragraph excludes the 875 mg dose when GFR is below 30 mL/min.

GFR / treatmentSelected dose expressed by amoxicillin component
10-30 mL/min250 or 500 mg every 12 hours, according to infection severity
Below 10 mL/min250 or 500 mg every 24 hours, according to infection severity
Hemodialysis250 or 500 mg every 24 hours; additional dose both during and at the end of dialysis

The adult 250 mg tablet and 250 mg chewable tablet have different clavulanate amounts. These instructions are not an AUGMENTIN XR or ES-600 conversion. Confirm the complete component strength, not amoxicillin milligrams alone.

RDM61-rxlist-amoxicillinclav-0a71e46ff2-C1 · Source locator: Dosage and Administration: renal impairment; named precautions

Source-specific limits

No new official-label card was obtained for this product in v6.1. Earlier source layers, if present, were retained but not rechecked.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/augmentin-drug/
Retrieved
2026-09-10
Renal-function method
GFR (mL/min), as printed
Source date/version
Revision not established in selected retrieval
Hash meaning
Local authored summary, not source HTML/XML/PDF bytes
Local summary SHA-256
23289e8ab6dc22065c0c1c0dc221c8cdabc06272b465dd9ac32f66113c89c5f2
Separate professional-source layer

University and professional protocols

Professional

UCSF - amoxicillin/clavulanate: standard and bloodstream-infection regimens

Open original reference

Open / share this exact local source

UCSF Infectious Diseases Management Program · Adults; oral immediate-release amoxicillin/clavulanate. Separate indication-specific institutional schedules.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Most indications: CrCl >30 mL/min, 875/125 mg orally twice daily; 10-29, 500/125 mg twice daily; <10, 500/125 mg daily. Intermittent HD: 500/125 mg initially then each evening; continuous HD: 500/125 mg twice daily.

The institution's separate Gram-negative bloodstream-infection regimen uses 875/125 mg three times daily at CrCl >30, twice daily at 10-29, and daily below 10. Its HD regimen is 875/125 mg initially then each evening; continuous HD uses that strength three times daily.

The 875-mg renal strategy for bloodstream infection is not interchangeable with standard U.S. product-label renal restrictions. Keep it under the named institutional indication. Exactly 30 is omitted in the source ranges.

RDM30-055-amoxicillinclav-1 · Source locator: UCSF - amoxicillin/clavulanate: standard and bloodstream-infection regimens; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/amoxicillin-clavulanate
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
ff118685a2a2e07b66036ff154c6f5ba9c83baf0d460f4ca4c4f1458879ca7f3

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/amoxicillinclav/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
08af6f1172537981bd4d5536a09124e3d37bb159ea1dd40d5f4591264e66c7dc
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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