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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Sodium chloride 3%

Monograph awaiting updateThis monograph will be updated in the future.

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Review note before using historical content

Historical article scope needs formulation review

The mapped sodium chloride article is broader than the 3% catalog record. Select concentration and clinical context explicitly.

Safety sources and review scope

Review-note ID: H62-HISTORY-SCOPE-SODIUM-CHLORIDE-3. The historical source remains preserved; this note does not qualify its complete monograph.

Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Sodium Chloride 3% (opens in a new tab)Original source URL: https://globalrph.com/dilution/sodium-chloride/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/sodium-chloride/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:50:44.691955+00:00
Source location
div.post-content
Packaged content SHA-256
cb712ee2fc849c9c91d6e127c448587ff620a9479a04d34b3cf59807b88919bf
Original response SHA-256
14c2d2cf3841372d6507e1f62d73547a9ceea98d9b49655fcc9452b23944c6a3
Source body SHA-256
841f71c2dd92dbc4b01003c0cb3ace3d25787ae8c7a5cd09a390fa6d8680e5fa
Historical product scope:
  • This broader historical sodium chloride article is linked to the older sodium-chloride-3 catalog entry. It is not exact-product reconciliation for every concentration in the article.

Sodium Chloride 3%
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
--

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
513 meq/ 1000 ml (3%)
See commentsCalculator or check out the custom calculator...

Stability / Miscellaneous
Sodium (normal range): 136 to 147 meq/l.The goal of treatment is to get the patient out of immediate danger (return sodium level to > 120 meq/l). Usually reserved for severe symptomatic hyponatremia (level usually < 115). The maximum rate of increase (sodium level) is 2 meq/L/hr. The usual rate is 0.5 to 1 meq/L/hr-- these lower rates help avoid serious CNS complications (cerebral edema, pontine myelinolysis,seizures) and/or pulmonary edema.

Always verify the infusion rate and the length of infusion based on patient weight and sodium level.

Calculation of the sodium deficit:
0.6 x weight(kg) x (desired Na+ - Actual Na+). Use 0.5 for females. Desired Na+= 120-125 meq/l.

Example: 70kg male. Na+= 110 meq/l Desired target= 125 meq/l.

[0.6 x 70kg x (125-110)= 630 meq of Na+ needed].

Amount needed to increase serum sodium level by 1 meq/l/hr= 0.6 x 70kg x 1.0= 42 meq/hr (safe rate for this patient).

3%--hypertonic saline contains 513 meq/liter.

Therefore: [desired rate per hr] / 513 x 1000 = infusion rate (ml/hr).
And the total infusion time= [total meq needed] / [meq/hr]

Desired rate= 42/513 meq x 1000= 82 ml/hr

Infusion time= [630 meq] / [42 meq/hr] = 15 hrs.

Therefore: Infuse 3% saline at 82 ml/hr for 15 hours.

Always verify the infusion rate and the length of infusion (using the calculations above) versus what is ordered.

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
monitor_or_titrate
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      sodium-chloride-3
      Source IDH51-4CD1D19742C7507279141C3A
      Generic name
      Sodium chloride 3%
      Source IDH51-75296413F617F0C03CCCBDF1
      Class
      Electrolytes and fluids
      Source IDH51-F4ADE61FB73A3B9D3610E5FF
      Subclass
      Hypertonic sodium chloride
      Source IDH51-084B65A7DF79263EF691E5CD
      Primary uses
      1. Severe symptomatic hyponatremia
        Source IDH51-4407E4DFEB8A64DF7B517886
      2. Intracranial hypertension and cerebral edema
        Source IDH51-F3686F8A95D96FC81ED30BD5
      Mechanism
      Raises extracellular sodium and osmolality and draws water from intracellular compartments.
      Source IDH51-3FA5980944163C5742380200
      Mechanism level
      drug_specific
      Source IDH51-36429F71403B805128B88A63
      Basic dosing orientation
      Adult symptomatic hyponatremia | Existing preparation record; use current package insert for indication-specific selection | Protocol bolus commonly 100 or 150 mL | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult neurocritical care | Existing preparation record; use current package insert for indication-specific selection | Bolus or continuous infusion per ICP/sodium protocol | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion
      Source IDH51-2997D6BB74E0B70954F3B3D3
      Administration orientation
      Bolus commonly over 10 to 20 minutes; repeat only per response and protocol; Pump-controlled, target-driven administration
      Source IDH51-90C4FC1E958107744E79C5C2
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal function materially affects toxicity, monitoring, or titration even when a fixed table may not apply.
      Source IDH51-29D0D740595AB28DE0A43525
      Key safety orientation
      1. Osmotic demyelination from overly rapid sodium correction.
        Source IDH51-5E4A0F66C9E3FC4FCA8B85E6
      2. Fluid overload and hyperchloremic acidosis.
        Source IDH51-F436768D9A646180E057D1C6
      3. Independent double check and pump guardrails are recommended.
        Source IDH51-457B1705F9A4F9000160CAE6
      Coverage path
      structured_local_snapshot
      Source IDH51-0FD0BBA0D493A5E3BC247E53
      Coverage path label
      Structured GlobalRPh route snapshot
      Source IDH51-7C3F357C646612C2411CEE06
      Legacy title
      Sodium chloride 3%
      Source IDH51-E80E9AE40ADD2A18F6E40787
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-3201D4961E8C298290D1545D
      Search text
      Sodium chloride 3% Electrolytes and fluids Hypertonic sodium chloride Severe symptomatic hyponatremia Intracranial hypertension and cerebral edema Raises extracellular sodium and osmolality and draws water from intracellular compartments. Adult symptomatic hyponatremia | Existing preparation record; use current package insert for indication-specific selection | Protocol bolus commonly 100 or 150 mL | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion; Adult neurocritical care | Existing preparation record; use current package insert for indication-specific selection | Bolus or continuous infusion per ICP/sodium protocol | Not normalized in the preparation record | See current package insert and professional guidance | IV infusion Bolus commonly over 10 to 20 minutes; repeat only per response and protocol; Pump-controlled, target-driven administration Renal function materially affects toxicity, monitoring, or titration even when a fixed table may not apply. Osmotic demyelination from overly rapid sodium correction. Fluid overload and hyperchloremic acidosis. Independent double check and pump guardrails are recommended. Structured GlobalRPh route snapshot
      Source IDH51-99CFB3E50EE55E8CB119D149
      Official access mode
      search
      Source IDH51-F0EF2868D5356796DEB1F491
      Official search query
      Sodium chloride 3%
      Source IDH51-584E869BAB17770DD1531B67
      Official access reason
      A source-backed DailyMed search is available; select and confirm the exact IV product.
      Source IDH51-EFC5799A41DFCAEE1B9C16CB

      No separate structured rows were bundled for IV push, continuous infusion, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical dilution and intermittent infusion preparation

      Recovered v5.1 source content; historical, awaiting current review.

      PopulationAmountReconstitutionDiluentFinal volumeConcentrationRateStabilityNotes
      Source IDH51-6868A826C9B0F349F2C4B3BD
      Adult symptomatic hyponatremia
      Source IDH51-49F0D052B86B1B953117DEFB
      		Protocol bolus commonly 100 or 150 mL
      Source IDH51-8058C784FC2E3588A403561C
      		Use commercially prepared 3% solution.
      Source IDH51-1919EFFFF07CE2CA93CF27CE
      		Ready-to-use
      Source IDH51-16D671F28545C625B4B09EFB
      		100 to 150 mL bolus or protocol infusion bag
      Source IDH51-E5938CC58CCB6EDA5E32224D
      		513 mEq/L sodium
      Source IDH51-F17118B420666F87E0D4B1CC
      		Bolus commonly over 10 to 20 minutes; repeat only per response and protocol
      Source IDH51-F96923106AF2F6B361F76048
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-7A8982E75DFD1DB517AFCCF3
      		Target controlled sodium correction; avoid overcorrection.
      Source IDH51-16234ECB25BEB7E4E624599B
      Source IDH51-6A8A9BBEB3539E598557203A
      Adult neurocritical care
      Source IDH51-0A8169B135AB11CF305D0514
      		Bolus or continuous infusion per ICP/sodium protocol
      Source IDH51-F5546F135D0479E291003B30
      		Use premixed solution.
      Source IDH51-42CE7C2F28C677C6E88383F5
      		Ready-to-use
      Source IDH51-FC031065A6180CEF850731B2
      		Protocol-specific
      Source IDH51-0A5C9C9E33ABB6BFF5FF8FB0
      		3%
      Source IDH51-6507176FD325F48A121F7BA6
      		Pump-controlled, target-driven administration
      Source IDH51-74452F2831C93F7A1BC34B9D
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-001F9B640D498A957AC7C31A
      		Central line may be preferred for prolonged/high-rate use, but peripheral administration may be allowed under institutional policy.
      Source IDH51-666FE0D2EC254C5A058CCD23
      Source IDH51-28DAA8CBBF357BB5656BE816
      Pediatric
      Source IDH51-69CF899284935E41D9BBD252
      		Weight-based bolus commonly 2 to 5 mL/kg depending on indication
      Source IDH51-285AEDDCB0C35DCC814AB1EA
      		Use premixed 3% solution.
      Source IDH51-36A63D902DC2977B7E75E0F8
      		Ready-to-use
      Source IDH51-B2329B93CC1558C42E5F0EA2
      		Weight-based
      Source IDH51-1393AA3D0C72E0CB7DF3E0E3
      		3%
      Source IDH51-017068857488AB4E6DF1458B
      		Over 10 to 20 minutes or per neurocritical care protocol
      Source IDH51-BD8F7424998B4D071C25981F
      		Use the shorter of current product labeling, validated stability data, and the applicable USP <797> sterility-based BUD ceiling.
      Source IDH51-49D3E0DC8C0514A2CCF21317

      Historical indication and population dosing

      Recovered tables and source-separated snapshots; full clinical revalidation remains pending.

      Existing dose and route snapshots

      RoutePopulationIndicationDoseIntervalDurationAdministrationSource levelNotes
      Source IDH51-86BFE519931E3954E8B1EA0B
      IV infusion
      Source IDH51-24AC95B4B0E12D3DAA9A3DE7
      		Adult symptomatic hyponatremia
      Source IDH51-EBBAE81B2CDBCFE140FBAFB3
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-C84E66DD8A20FF8AFD556E47
      		Protocol bolus commonly 100 or 150 mL
      Source IDH51-C1D13C0F5647537171FA3751
      		Not normalized in the preparation record
      Source IDH51-DA3DFBD78FFBDAC0B49F294E
      		See current package insert and professional guidance
      Source IDH51-EE2AF43EB280944CC67793C6
      		Bolus commonly over 10 to 20 minutes; repeat only per response and protocol
      Source IDH51-3ACD2AD2C2B45702A70BF61E
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-D9991D06DABB9FE247AAFF05
      		Target controlled sodium correction; avoid overcorrection.
      Source IDH51-25D0462C946162BC0371D710
      Source IDH51-BDF670D6D8132DBE18491E2D
      IV infusion
      Source IDH51-D6024990C53887DA9F3D66B1
      		Adult neurocritical care
      Source IDH51-428F4546AA8C5D7B767AF035
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-ECFFA5E6E50247AF17719B86
      		Bolus or continuous infusion per ICP/sodium protocol
      Source IDH51-78D78BE881F4C69AD5526A5F
      		Not normalized in the preparation record
      Source IDH51-E1DEE099C762B3E62013257A
      		See current package insert and professional guidance
      Source IDH51-143AFE026B7C837BAE0FA6FB
      		Pump-controlled, target-driven administration
      Source IDH51-EF9C133096C96023CB5D105E
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-535FDBE3396F182103F957F1
      		Central line may be preferred for prolonged/high-rate use, but peripheral administration may be allowed under institutional policy.
      Source IDH51-5F5C0214C6AD8F8548CA2587
      Source IDH51-FAF45A36B76529D1C267568A
      IV infusion
      Source IDH51-A57E9853754D4290ABA28F99
      		Pediatric
      Source IDH51-C523721FA98A976D7235C1F0
      		Existing preparation record; use current package insert for indication-specific selection
      Source IDH51-5D7DA6772088691977850A85
      		Weight-based bolus commonly 2 to 5 mL/kg depending on indication
      Source IDH51-CA93B97F7B230359C3795FB3
      		Not normalized in the preparation record
      Source IDH51-652B93314E5ADBBD792934FA
      		See current package insert and professional guidance
      Source IDH51-F6EF267D01FAB843EAC8D3BD
      		Over 10 to 20 minutes or per neurocritical care protocol
      Source IDH51-774A7DE0A0CF59074C965A56
      		Existing GlobalRPh structured preparation snapshot
      Source IDH51-91CA6431A7529118047ECCB3

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      monitor_or_titrate
      Source IDH51-0DCA6215F06BC5C3040E9900
      Summary
      Renal function materially affects toxicity, monitoring, or titration even when a fixed table may not apply.
      Source IDH51-1C6BFFA25E265505AD93A4B4
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-A856EAE3E495933BB305CED0

      Historical Common IV uses

      Recovered v5.1 source content; historical, awaiting current review.

      1. Severe symptomatic hyponatremia
        Source IDH51-4289AA08EF68714B6DCDF6E4
      2. Intracranial hypertension and cerebral edema
        Source IDH51-2DFA82D37721C6DB0F46FFD5

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Osmotic demyelination from overly rapid sodium correction.
        Source IDH51-070FDAD3DD69508941FB1DDF
      2. Fluid overload and hyperchloremic acidosis.
        Source IDH51-4E6DC1A05A2F6BB6F4D4F510
      3. Independent double check and pump guardrails are recommended.
        Source IDH51-43BDC258F4A039E18634070C

      Historical Monitoring

      Recovered v5.1 source content; historical, awaiting current review.

      1. Serum sodium at protocol-defined intervals
        Source IDH51-F70D42901A596826376E33B5
      2. Neurologic status
        Source IDH51-9A7E083C7107F35435F7B1C6
      3. Fluid balance and IV site
        Source IDH51-176887C911DDDEC493A35245
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      sodium-chloride-3
      Source IDH51-FBDB7337A05FFFB11D788D78
      Generic name
      Sodium chloride 3%
      Source IDH51-10C457E029862C103807FF64
      Brand names
      1. Hypertonic saline
        Source IDH51-5318D0A738C43F96DC3BD8CA
      Aliases
      1. 3% saline
        Source IDH51-C0AB4B30131059F7AB5701FE
      Class
      Electrolytes and fluids
      Source IDH51-263BF0287461F2B02892B0A3
      Subclass
      Hypertonic sodium chloride
      Source IDH51-134CFF4EBAF563CD15F7B39A
      Summary
      High-alert hypertonic fluid used for severe symptomatic hyponatremia and intracranial hypertension under protocolized monitoring.
      Source IDH51-540E316E3E5A36A0D93ADA27
      Populations
      1. Adult
        Source IDH51-3E096E2CC84DDAAC0260A25B
      2. Pediatric
        Source IDH51-CC8C629AC5CA83AB4368247D
      Evidence tier
      Core reference - verify current label
      Source IDH51-94B9B7A8926AFF8798B09D7A
      High alert
      true
      Source IDH51-C610308ADFED97DEA74A4A20
      Hazardous
      false
      Source IDH51-5299B5D633B17586976A176F
      Status
      Active
      Source IDH51-2AE19E7760E39D503B16CDA6
      Reviewed
      2026-08-29
      Source IDH51-06367D25F7BDD8A8832A1DC6
      Version added
      1.0
      Source IDH51-5137AA4668F952B866E4E43C
      Sources
      LabelUrlKind
      Source IDH51-9A7C42225AE21DD489014235
      DailyMed label search
      Source IDH51-52E873313CE6FAEC550C21E7
      		https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Sodium+chloride+3%25 (opens in a new tab)
      Source IDH51-9653FE4A01FCF7B2AB35F4B6
      		Primary
      Source IDH51-1303C860E9D59543A333056A
      Source IDH51-85DC3AE19FF8336DA48F2C7E
      GlobalRPh legacy IV dilution monograph
      Source IDH51-706D5401E3FA9E64DCB39B58
      		legacy:auto
      Source IDH51-9F0F44D5E169FE44899930BE
      		Legacy
      Source IDH51-A17970506E47D8243781E4D3
      Legacy title
      Sodium chloride 3%
      Source IDH51-682B16BFC6454E0019C4B1F6
      Clinical release verification
      Audit version
      3.4
      Source IDH51-5C09859F66C5625C3D192286
      Audited on
      2026-08-30
      Source IDH51-36535478E014FFC9ED02694B
      Level
      amber
      Source IDH51-D2A89598414B7C204BD35B30
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-F214D45BAC03148E47EA073D
      Exact current label candidate
      false
      Source IDH51-041AB7528B1BFFEB8A5AF730
      Numeric support ratio
      0
      Source IDH51-51206B493F60BB7C3E77BEDB
      Reference url count
      1
      Source IDH51-81EF91EBEEBC629E40A784C1
      Broken reference count
      0
      Source IDH51-E582FFCADBB3DC4D71799F07
      Point of use confirmation required
      true
      Source IDH51-D69379FC1BBE8B0FE3CAF14E
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-80760F5877617BA29DE7334C

      Dosing source fields

      Id
      sodium-chloride-3
      Source IDH51-B327C26F3EC96250F34B699B
      Generic name
      Sodium chloride 3%
      Source IDH51-174A82ACACCABB4D74E1EF22
      Coverage status
      direct_official_label_access_plus_local_snapshot
      Source IDH51-32426AEADD74C483C5A7C2A2
      Package insert
      Query name
      Sodium chloride 3%
      Source IDH51-C49674C36773A3EFFC97D9EE
      Product and route must match
      true
      Source IDH51-A39647096DB74A70C7660EB2
      Live current label enabled
      false
      Source IDH51-B3089AE67F397B5143898164
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-0554F6BE8CD00C91C44AA694
      Direct official label access enabled
      true
      Source IDH51-C3847CC864D171FFC71A225A
      Outbound server request required
      false
      Source IDH51-35956ACD71B73F77CD01F352
      Local summary status
      not_bundled
      Source IDH51-6B99EC7863B9F63F18EEDA41
      Clinical review
      Locally normalized
      false
      Source IDH51-E042A2581E9B70B56A927078
      Reviewed
      2026-08-29
      Source IDH51-075BBDDBF85EB128905D622C
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-83BE1AD98249075F15CB8C19
      Clinical release verification
      Audit version
      3.4
      Source IDH51-C03FAFD918EC68689C2929EA
      Audited on
      2026-08-30
      Source IDH51-94B6CF23BE841D12EA81E60D
      Level
      amber
      Source IDH51-3DB6780FEE5EE3BC04B9EAC4
      Release gate
      trusted_professional_source_present_exact_label_unconfirmed
      Source IDH51-F6B88D9B01625FA3B2E9F0B3
      Exact current label candidate
      false
      Source IDH51-9CBB2226540217E584DB381D
      Numeric support ratio
      0
      Source IDH51-EB3BC3586D0A5BD76DB01E3B
      Reference url count
      1
      Source IDH51-4F767A0D1CA236C51D5F306D
      Broken reference count
      0
      Source IDH51-844879CA6505F74B3F0AC671
      Point of use confirmation required
      true
      Source IDH51-E017704462295C6F0B9A58F6
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-67A242753146C561A485E298
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      sodium-chloride-3
      Source IDH51-F805ED17231F4876868B5FC7
      Name
      Sodium chloride 3%
      Source IDH51-605C0476D129A037ED577EEE
      Brands
      Hypertonic saline
      Source IDH51-74E4A289319782B458D33317
      Therapeutic class
      Electrolytes and fluids
      Source IDH51-FE7D920C8E0A5FB190814139
      Review version
      3.1
      Source IDH51-351F7AFC7D26C56C6A3F703A
      Review date
      2026-08-30
      Source IDH51-457A206C01C960D1DE4AA15E
      Release status
      structured_record_current_label_not_confirmed
      Source IDH51-B17A2AC479DBE1C9A9B0F2A1
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-01F29FA22761BF1F112265D6
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-6F1F82C904A36762BDB95A28
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-24299D331D8D5F05743CD799
      Reconstitution concentration
      Use commercially prepared 3% solution. Use premixed solution. Use premixed 3% solution.
      Source IDH51-8F73876FD99C0A72AB096FBE
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-4269BE3FCA43FA90A527F7C7
      Appropriate standardized containers
      100 to 150 mL bolus or protocol infusion bag Protocol-specific Weight-based
      Source IDH51-DC5584FEF552297D0F4F8788
      Adult dosing range
      Protocol bolus commonly 100 or 150 mL Bolus or continuous infusion per ICP/sodium protocol Weight-based bolus commonly 2 to 5 mL/kg depending on indication
      Source IDH51-94467AA6D4A4D2BB769F48E6
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-22E36248C34F2A29CB060394
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-3D5BA69D7F9714DE83E478EF
      Infusion time
      Bolus commonly over 10 to 20 minutes; repeat only per response and protocol Pump-controlled, target-driven administration Over 10 to 20 minutes or per neurocritical care protocol
      Source IDH51-3E0BC56095FA88794673014B
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-DEE9430C00B88DBC08178EC7
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-64FB452514747BDAB774B2B0
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-CCE2F96AED13609E0CE68791
      Reconstitution concentration
      Primary
      existing_structured_record
      Source IDH51-E1776EF5EEA916E7BC65173F
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-74E43755ECD765BCE62E6A48
      Appropriate standardized containers
      Primary
      existing_structured_record
      Source IDH51-8A0B09824FF4D5567F0C4C72
      Adult dosing range
      Primary
      existing_structured_record
      Source IDH51-643272596F8338EFFE197EF8
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-45158CD0F1530B0D653CC020
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-455ED89EFC21536FD2EECB5D
      Infusion time
      Primary
      existing_structured_record
      Source IDH51-18B460EF439B8C2651FBB3CD
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-A5638DC7C020AE7F9EF44EBD
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-8CF93F10560F3AEF32C6C0D7
      Population applicability
      Adult
      Applicability
      supported_or_source_present
      Source IDH51-D0B770A5AF25056D5D1A78FD
      Guide generation allowed
      true
      Source IDH51-E527B0A3EA4C8E8AA0DD2857
      Pediatric
      Applicability
      supported_or_source_present
      Source IDH51-956EEA636122A0960A22E14D
      Guide generation allowed
      false
      Source IDH51-14C8709C50A9AB5ED38DB7B3
      Neonatal
      Applicability
      not_established
      Source IDH51-69A35CF8AE01E0D194CA4EFF
      Guide generation allowed
      false
      Source IDH51-3667ACA68EA1A05BCB962067
      Route presence
      Structured dilution
      true
      Source IDH51-EB3FF0EB391961AD85E1430F
      Iv push
      false
      Source IDH51-B497F452475B95E03978E228
      Continuous infusion
      true
      Source IDH51-921C6E53AD76B757E6DC2BB6
      Pediatric source
      true
      Source IDH51-0D1F931796D44BD1EFD21827
      Neonatal source
      false
      Source IDH51-81A67A51733EE1BE018131BA
      Legacy reference
      Status
      not_available
      Source IDH51-944B7B381D1C9BA9B9E518BE
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-90C75C643B18AD1156CEE650
      Source files
      1. catalog.json
        Source IDH51-308E80CE2C68A97B7B0F0D0D
      2. dosing.json
        Source IDH51-1FC716D4B31FA5AB2BF6C371
      3. legacy-map.json
        Source IDH51-27DFF1AAE89CA3BBCB659BF7
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-5A1A09C60B2353139434E15F
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-FBDB7337A05FFFB11D788D78catalog.json
      /records/224/id      		Historical; current review incomplete
      H51-10C457E029862C103807FF64catalog.json
      /records/224/generic_name      		Historical; current review incomplete
      H51-5318D0A738C43F96DC3BD8CAcatalog.json
      /records/224/brand_names/0      		Historical; current review incomplete
      H51-C0AB4B30131059F7AB5701FEcatalog.json
      /records/224/aliases/0      		Historical; current review incomplete
      H51-263BF0287461F2B02892B0A3catalog.json
      /records/224/class      		Historical; current review incomplete
      H51-134CFF4EBAF563CD15F7B39Acatalog.json
      /records/224/subclass      		Historical; current review incomplete
      H51-540E316E3E5A36A0D93ADA27catalog.json
      /records/224/summary      		Historical; current review incomplete
      H51-4289AA08EF68714B6DCDF6E4catalog.json
      /records/224/common_uses/0      		Historical; current review incomplete
      H51-2DFA82D37721C6DB0F46FFD5catalog.json
      /records/224/common_uses/1      		Historical; current review incomplete
      H51-6868A826C9B0F349F2C4B3BDcatalog.json
      /records/224/preparations/0      		Historical; current review incomplete
      H51-49F0D052B86B1B953117DEFBcatalog.json
      /records/224/preparations/0/population      		Historical; current review incomplete
      H51-8058C784FC2E3588A403561Ccatalog.json
      /records/224/preparations/0/amount      		Historical; current review incomplete
      H51-1919EFFFF07CE2CA93CF27CEcatalog.json
      /records/224/preparations/0/reconstitution      		Historical; current review incomplete
      H51-16D671F28545C625B4B09EFBcatalog.json
      /records/224/preparations/0/diluent      		Historical; current review incomplete
      H51-E5938CC58CCB6EDA5E32224Dcatalog.json
      /records/224/preparations/0/final_volume      		Historical; current review incomplete
      H51-F17118B420666F87E0D4B1CCcatalog.json
      /records/224/preparations/0/concentration      		Historical; current review incomplete
      H51-F96923106AF2F6B361F76048catalog.json
      /records/224/preparations/0/rate      		Historical; current review incomplete
      H51-7A8982E75DFD1DB517AFCCF3catalog.json
      /records/224/preparations/0/stability      		Historical; current review incomplete
      H51-16234ECB25BEB7E4E624599Bcatalog.json
      /records/224/preparations/0/notes      		Historical; current review incomplete
      H51-6A8A9BBEB3539E598557203Acatalog.json
      /records/224/preparations/1      		Historical; current review incomplete
      H51-0A8169B135AB11CF305D0514catalog.json
      /records/224/preparations/1/population      		Historical; current review incomplete
      H51-F5546F135D0479E291003B30catalog.json
      /records/224/preparations/1/amount      		Historical; current review incomplete
      H51-42CE7C2F28C677C6E88383F5catalog.json
      /records/224/preparations/1/reconstitution      		Historical; current review incomplete
      H51-FC031065A6180CEF850731B2catalog.json
      /records/224/preparations/1/diluent      		Historical; current review incomplete
      H51-0A5C9C9E33ABB6BFF5FF8FB0catalog.json
      /records/224/preparations/1/final_volume      		Historical; current review incomplete
      H51-6507176FD325F48A121F7BA6catalog.json
      /records/224/preparations/1/concentration      		Historical; current review incomplete
      H51-74452F2831C93F7A1BC34B9Dcatalog.json
      /records/224/preparations/1/rate      		Historical; current review incomplete
      H51-001F9B640D498A957AC7C31Acatalog.json
      /records/224/preparations/1/stability      		Historical; current review incomplete
      H51-666FE0D2EC254C5A058CCD23catalog.json
      /records/224/preparations/1/notes      		Historical; current review incomplete
      H51-28DAA8CBBF357BB5656BE816catalog.json
      /records/224/preparations/2      		Historical; current review incomplete
      H51-69CF899284935E41D9BBD252catalog.json
      /records/224/preparations/2/population      		Historical; current review incomplete
      H51-285AEDDCB0C35DCC814AB1EAcatalog.json
      /records/224/preparations/2/amount      		Historical; current review incomplete
      H51-36A63D902DC2977B7E75E0F8catalog.json
      /records/224/preparations/2/reconstitution      		Historical; current review incomplete
      H51-B2329B93CC1558C42E5F0EA2catalog.json
      /records/224/preparations/2/diluent      		Historical; current review incomplete
      H51-1393AA3D0C72E0CB7DF3E0E3catalog.json
      /records/224/preparations/2/final_volume      		Historical; current review incomplete
      H51-017068857488AB4E6DF1458Bcatalog.json
      /records/224/preparations/2/concentration      		Historical; current review incomplete
      H51-BD8F7424998B4D071C25981Fcatalog.json
      /records/224/preparations/2/rate      		Historical; current review incomplete
      H51-49D3E0DC8C0514A2CCF21317catalog.json
      /records/224/preparations/2/stability      		Historical; current review incomplete
      H51-09F496F14D210988F3E885C2catalog.json
      /records/224/preparations/2/notes      		Historical; current review incomplete
      H51-070FDAD3DD69508941FB1DDFcatalog.json
      /records/224/warnings/0      		Historical; current review incomplete
      H51-4E6DC1A05A2F6BB6F4D4F510catalog.json
      /records/224/warnings/1      		Historical; current review incomplete
      H51-43BDC258F4A039E18634070Ccatalog.json
      /records/224/warnings/2      		Historical; current review incomplete
      H51-F70D42901A596826376E33B5catalog.json
      /records/224/monitoring/0      		Historical; current review incomplete
      H51-9A7E083C7107F35435F7B1C6catalog.json
      /records/224/monitoring/1      		Historical; current review incomplete
      H51-176887C911DDDEC493A35245catalog.json
      /records/224/monitoring/2      		Historical; current review incomplete
      H51-3E096E2CC84DDAAC0260A25Bcatalog.json
      /records/224/populations/0      		Historical; current review incomplete
      H51-CC8C629AC5CA83AB4368247Dcatalog.json
      /records/224/populations/1      		Historical; current review incomplete
      H51-94B9B7A8926AFF8798B09D7Acatalog.json
      /records/224/evidence_tier      		Historical; current review incomplete
      H51-C610308ADFED97DEA74A4A20catalog.json
      /records/224/high_alert      		Historical; current review incomplete
      H51-5299B5D633B17586976A176Fcatalog.json
      /records/224/hazardous      		Historical; current review incomplete
      H51-2AE19E7760E39D503B16CDA6catalog.json
      /records/224/status      		Historical; current review incomplete
      H51-06367D25F7BDD8A8832A1DC6catalog.json
      /records/224/reviewed      		Historical; current review incomplete
      H51-5137AA4668F952B866E4E43Ccatalog.json
      /records/224/version_added      		Historical; current review incomplete
      H51-9A7C42225AE21DD489014235catalog.json
      /records/224/sources/0      		Historical; current review incomplete
      H51-52E873313CE6FAEC550C21E7catalog.json
      /records/224/sources/0/label      		Historical; current review incomplete
      H51-9653FE4A01FCF7B2AB35F4B6catalog.json
      /records/224/sources/0/url      		Historical; current review incomplete
      H51-1303C860E9D59543A333056Acatalog.json
      /records/224/sources/0/kind      		Historical; current review incomplete
      H51-85DC3AE19FF8336DA48F2C7Ecatalog.json
      /records/224/sources/1      		Historical; current review incomplete
      H51-706D5401E3FA9E64DCB39B58catalog.json
      /records/224/sources/1/label      		Historical; current review incomplete
      H51-9F0F44D5E169FE44899930BEcatalog.json
      /records/224/sources/1/url      		Historical; current review incomplete
      H51-A17970506E47D8243781E4D3catalog.json
      /records/224/sources/1/kind      		Historical; current review incomplete
      H51-682B16BFC6454E0019C4B1F6catalog.json
      /records/224/legacy_title      		Historical; current review incomplete
      H51-5C09859F66C5625C3D192286catalog.json
      /records/224/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-36535478E014FFC9ED02694Bcatalog.json
      /records/224/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-D2A89598414B7C204BD35B30catalog.json
      /records/224/clinical_release_verification/level      		Historical; current review incomplete
      H51-F214D45BAC03148E47EA073Dcatalog.json
      /records/224/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-041AB7528B1BFFEB8A5AF730catalog.json
      /records/224/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-295D4520F99ABEF04553EF80catalog.json
      /records/224/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-A11F5C4C4BF725AAF14238A7catalog.json
      /records/224/clinical_release_verification/selected_label_title      		Historical; current review incomplete
      H51-51206B493F60BB7C3E77BEDBcatalog.json
      /records/224/clinical_release_verification/numeric_support_ratio      		Historical; current review incomplete
      H51-81EF91EBEEBC629E40A784C1catalog.json
      /records/224/clinical_release_verification/reference_url_count      		Historical; current review incomplete
      H51-E582FFCADBB3DC4D71799F07catalog.json
      /records/224/clinical_release_verification/broken_reference_count      		Historical; current review incomplete
      H51-D69379FC1BBE8B0FE3CAF14Ecatalog.json
      /records/224/clinical_release_verification/point_of_use_confirmation_required      		Historical; current review incomplete
      H51-80760F5877617BA29DE7334Ccatalog.json
      /records/224/clinical_release_verification/note      		Historical; current review incomplete
      H51-0E9B1BF66052C195F292F757catalog.json
      /records/224/clinical_release_verification/dailymed_search_url      		Historical; current review incomplete
      H51-B327C26F3EC96250F34B699Bdosing.json
      /records/224/id      		Historical; current review incomplete
      H51-174A82ACACCABB4D74E1EF22dosing.json
      /records/224/generic_name      		Historical; current review incomplete
      H51-32426AEADD74C483C5A7C2A2dosing.json
      /records/224/coverage_status      		Historical; current review incomplete
      H51-C49674C36773A3EFFC97D9EEdosing.json
      /records/224/package_insert/query_name      		Historical; current review incomplete
      H51-AABFE99E2B01349AFA8E60BEdosing.json
      /records/224/package_insert/preferred_setid      		Historical; current review incomplete
      H51-A39647096DB74A70C7660EB2dosing.json
      /records/224/package_insert/product_and_route_must_match      		Historical; current review incomplete
      H51-B3089AE67F397B5143898164dosing.json
      /records/224/package_insert/live_current_label_enabled      		Historical; current review incomplete
      H51-0554F6BE8CD00C91C44AA694dosing.json
      /records/224/package_insert/source_priority      		Historical; current review incomplete
      H51-C3847CC864D171FFC71A225Adosing.json
      /records/224/package_insert/direct_official_label_access_enabled      		Historical; current review incomplete
      H51-35956ACD71B73F77CD01F352dosing.json
      /records/224/package_insert/outbound_server_request_required      		Historical; current review incomplete
      H51-6B99EC7863B9F63F18EEDA41dosing.json
      /records/224/package_insert/local_summary_status      		Historical; current review incomplete
      H51-0DCA6215F06BC5C3040E9900dosing.json
      /records/224/renal/classification      		Historical; current review incomplete
      H51-1C6BFFA25E265505AD93A4B4dosing.json
      /records/224/renal/summary      		Historical; current review incomplete
      H51-A856EAE3E495933BB305CED0dosing.json
      /records/224/renal/method_note      		Historical; current review incomplete
      H51-86BFE519931E3954E8B1EA0Bdosing.json
      /records/224/existing_route_snapshots/0      		Historical; current review incomplete
      H51-24AC95B4B0E12D3DAA9A3DE7dosing.json
      /records/224/existing_route_snapshots/0/route      		Historical; current review incomplete
      H51-EBBAE81B2CDBCFE140FBAFB3dosing.json
      /records/224/existing_route_snapshots/0/population      		Historical; current review incomplete
      H51-C84E66DD8A20FF8AFD556E47dosing.json
      /records/224/existing_route_snapshots/0/indication      		Historical; current review incomplete
      H51-C1D13C0F5647537171FA3751dosing.json
      /records/224/existing_route_snapshots/0/dose      		Historical; current review incomplete
      H51-DA3DFBD78FFBDAC0B49F294Edosing.json
      /records/224/existing_route_snapshots/0/interval      		Historical; current review incomplete
      H51-EE2AF43EB280944CC67793C6dosing.json
      /records/224/existing_route_snapshots/0/duration      		Historical; current review incomplete
      H51-3ACD2AD2C2B45702A70BF61Edosing.json
      /records/224/existing_route_snapshots/0/administration      		Historical; current review incomplete
      H51-D9991D06DABB9FE247AAFF05dosing.json
      /records/224/existing_route_snapshots/0/source_level      		Historical; current review incomplete
      H51-25D0462C946162BC0371D710dosing.json
      /records/224/existing_route_snapshots/0/notes      		Historical; current review incomplete
      H51-BDF670D6D8132DBE18491E2Ddosing.json
      /records/224/existing_route_snapshots/1      		Historical; current review incomplete
      H51-D6024990C53887DA9F3D66B1dosing.json
      /records/224/existing_route_snapshots/1/route      		Historical; current review incomplete
      H51-428F4546AA8C5D7B767AF035dosing.json
      /records/224/existing_route_snapshots/1/population      		Historical; current review incomplete
      H51-ECFFA5E6E50247AF17719B86dosing.json
      /records/224/existing_route_snapshots/1/indication      		Historical; current review incomplete
      H51-78D78BE881F4C69AD5526A5Fdosing.json
      /records/224/existing_route_snapshots/1/dose      		Historical; current review incomplete
      H51-E1DEE099C762B3E62013257Adosing.json
      /records/224/existing_route_snapshots/1/interval      		Historical; current review incomplete
      H51-143AFE026B7C837BAE0FA6FBdosing.json
      /records/224/existing_route_snapshots/1/duration      		Historical; current review incomplete
      H51-EF9C133096C96023CB5D105Edosing.json
      /records/224/existing_route_snapshots/1/administration      		Historical; current review incomplete
      H51-535FDBE3396F182103F957F1dosing.json
      /records/224/existing_route_snapshots/1/source_level      		Historical; current review incomplete
      H51-5F5C0214C6AD8F8548CA2587dosing.json
      /records/224/existing_route_snapshots/1/notes      		Historical; current review incomplete
      H51-FAF45A36B76529D1C267568Adosing.json
      /records/224/existing_route_snapshots/2      		Historical; current review incomplete
      H51-A57E9853754D4290ABA28F99dosing.json
      /records/224/existing_route_snapshots/2/route      		Historical; current review incomplete
      H51-C523721FA98A976D7235C1F0dosing.json
      /records/224/existing_route_snapshots/2/population      		Historical; current review incomplete
      H51-5D7DA6772088691977850A85dosing.json
      /records/224/existing_route_snapshots/2/indication      		Historical; current review incomplete
      H51-CA93B97F7B230359C3795FB3dosing.json
      /records/224/existing_route_snapshots/2/dose      		Historical; current review incomplete
      H51-652B93314E5ADBBD792934FAdosing.json
      /records/224/existing_route_snapshots/2/interval      		Historical; current review incomplete
      H51-F6EF267D01FAB843EAC8D3BDdosing.json
      /records/224/existing_route_snapshots/2/duration      		Historical; current review incomplete
      H51-774A7DE0A0CF59074C965A56dosing.json
      /records/224/existing_route_snapshots/2/administration      		Historical; current review incomplete
      H51-91CA6431A7529118047ECCB3dosing.json
      /records/224/existing_route_snapshots/2/source_level      		Historical; current review incomplete
      H51-C1090410A6638F49EFF5E414dosing.json
      /records/224/existing_route_snapshots/2/notes      		Historical; current review incomplete
      H51-E042A2581E9B70B56A927078dosing.json
      /records/224/clinical_review/locally_normalized      		Historical; current review incomplete
      H51-075BBDDBF85EB128905D622Cdosing.json
      /records/224/clinical_review/reviewed      		Historical; current review incomplete
      H51-83BE1AD98249075F15CB8C19dosing.json
      /records/224/clinical_review/status      		Historical; current review incomplete
      H51-C03FAFD918EC68689C2929EAdosing.json
      /records/224/clinical_release_verification/audit_version      		Historical; current review incomplete
      H51-94B6CF23BE841D12EA81E60Ddosing.json
      /records/224/clinical_release_verification/audited_on      		Historical; current review incomplete
      H51-3DB6780FEE5EE3BC04B9EAC4dosing.json
      /records/224/clinical_release_verification/level      		Historical; current review incomplete
      H51-F6B88D9B01625FA3B2E9F0B3dosing.json
      /records/224/clinical_release_verification/release_gate      		Historical; current review incomplete
      H51-9CBB2226540217E584DB381Ddosing.json
      /records/224/clinical_release_verification/exact_current_label_candidate      		Historical; current review incomplete
      H51-0342CC2A61311EA2CF13D1E4dosing.json
      /records/224/clinical_release_verification/selected_setid      		Historical; current review incomplete
      H51-2EFDD7F4F61975E7A23D957Ddosing.json
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      H51-4CD1D19742C7507279141C3Afirst-look-v5.1.json
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      /224/clinical_release_note      		Historical; current review incomplete

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