GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Tecovirimat - TPOXX intravenous injection

Local official-label summaryBase record retrieved 2026-09-09See the evidence for this drug2 sources available - open source summaries, references and comparisons

TPOXX injection / tecovirimat IV / TPOXX IV

READ THE SOURCE-SPECIFIC ANSWER

Renal guidance at a glance

Cautions / source differences (1)
Review first - source-specific qualification

Check IV eligibility before reading no-adjustment wording

The injection has a severe-renal contraindication even though the oral product has a broader no-adjustment statement.

Before applying: Keep excipient precautions, monitoring and the IV cutoff attached.

Evidence for this qualification

Source-specific qualification; independent clinician review pending.

Confirm the product, indication and renal measure. The selected summary is not a complete prescribing monograph.

Choose a source to read (2)

Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

Official source

DailyMed / TPOXX exact oral and injection label

Product / population
TPOXX injection for labeled human smallpox treatment in patients weighing at least 3 kg; not an oral-capsule or mpox treatment protocol.
Renal measure
CrCl, mL/min; injection-specific excipient restriction

Selected sections only. Source mirror and underlying label are not independent confirmations.

Renal dosing, restrictions and evidence limits

For IV TPOXX, CrCl below 30 mL/min is a contraindication. Mild (60-89) and moderate (30-59 mL/min) impairment do not require dose adjustment, but the hydroxypropyl-beta-cyclodextrin excipient still warrants caution and renal monitoring. Determine CrCl before IV treatment and monitor as clinically appropriate. Consider conversion to oral treatment once tolerated. Pediatric patients under 2 years have additional excipient/renal-maturity precautions.

Source revision: 4/2024 | Retrieved: 2026-09-09. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fce826ab-4d6a-4139-a2ee-a304a913a253

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

Full source card / provenance

All sources, comparison tools and evidence navigation
Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 1 source difference / applicability notes

Official product label

DailyMed / TPOXX exact oral and injection label

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

TPOXX injection for labeled human smallpox treatment in patients weighing at least 3 kg; not an oral-capsule or mpox treatment protocol.

Renal method: CrCl, mL/min; injection-specific excipient restriction
Retrieved: 2026-09-09

Read local renal resultOpen original reference
GlobalRPh RX List

GlobalRPh RX List - TPOXX injection

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

TPOXX injection for labeled human smallpox treatment in patients weighing at least 3 kg; not an oral-capsule or mpox treatment protocol.

Renal method: CrCl, mL/min; injection-specific excipient restriction
Retrieved: 2026-09-09

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Product / population check

Confirm the exact formulation before using a renal source

These links compare product identities, not interchangeable doses. A selected summary is not a complete prescribing monograph.

Source-specific review points

Check IV eligibility before reading no-adjustment wording

Read the attributed comparison notes and source cards below. No conflict has been silently adjudicated.

Source-quality holds
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Search the stored clinical text

Locate a word or phrase within this drug's source summaries. Choose all sources or one source to focus the search. The selection never hides warnings or source text, changes a dose, or proves that a renal finding is absent.

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All source summaries, original wording and provenance
Before applying a renal protocol

Check the setting. Compare whole sources.

No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.

Share a reproducible source review

Choose sources below, then open a print-ready comparison with product scope, renal method, dates and cautions. Links can pin the exact local cards; they never contain patient values or choose a dose.

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Jump to renal guidanceRead 1 difference / caution notesClinician guide

Select two distinct source versions. The complete stored summaries will appear below.

Build a source-review outline for documentation

This creates a blank decision outline with the source identities you select, not a dose recommendation or completed clinical assessment. No patient fields are collected, saved or sent. Complete the clinical decisions in your approved documentation system.

Choose one or two sources above or use the source checkboxes below.

Renal-context checklist: population, kidney trend and dialysis

These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.

Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.

See source-specific renal methods and the clinical interpretation guide for the supporting context.

Read before choosing a regimen

Source differences and product cautions

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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

Go directly to the relevant source section

Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeDailyMed / TPOXX exact oral and injection labelGlobalRPh RX List - TPOXX injection
Choose two source checkboxes below.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/tpoxx-drug/

Exact product and population

TPOXX injection for labeled human smallpox treatment in patients weighing at least 3 kg; not an oral-capsule or mpox treatment protocol.

RDM54-SCOPE-tecovirimat-tpoxx-iv · Source section: Selected source product scopeRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

DailyMed / TPOXX exact oral and injection label

Open original reference

Open / share this exact local source

DailyMed / SIGA Technologies, Inc. · TPOXX injection for labeled human smallpox treatment in patients weighing at least 3 kg; not an oral-capsule or mpox treatment protocol.

Renal method: CrCl, mL/min; injection-specific excipient restriction
Source date: 4/2024
Retrieved: 2026-09-09

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For IV TPOXX, CrCl below 30 mL/min is a contraindication. Mild (60-89) and moderate (30-59 mL/min) impairment do not require dose adjustment, but the hydroxypropyl-beta-cyclodextrin excipient still warrants caution and renal monitoring. Determine CrCl before IV treatment and monitor as clinically appropriate. Consider conversion to oral treatment once tolerated. Pediatric patients under 2 years have additional excipient/renal-maturity precautions.

RDM54-official-tecovirimat-tpoxx-iv-26099d5aef-C1 · Source locator: Sections 2.1, 2.2, 2.4, 4, 5.2 and 8.6

Source-specific limits

Selected sections only. Source mirror and underlying label are not independent confirmations.

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fce826ab-4d6a-4139-a2ee-a304a913a253
Retrieved
2026-09-09
Exact label title
TPOXX - tecovirimat monohydrate injection, solution, concentrate; TPOXX - tecovirimat monohydrate capsule
DailyMed Set ID
fce826ab-4d6a-4139-a2ee-a304a913a253
Labeler
SIGA Technologies, Inc.
DailyMed page updated
2025-12-31
Label revision
4/2024
Renal-function method
CrCl, mL/min; injection-specific excipient restriction
Source date/version
4/2024
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
9cba02ee925653ad8fa6e00419f99adc129a00be01514916bc6d02a012b3878c
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - TPOXX injection

Open original reference

Open / share this exact local source

GlobalRPh-hosted RX List · TPOXX injection for labeled human smallpox treatment in patients weighing at least 3 kg; not an oral-capsule or mpox treatment protocol.

Renal method: CrCl, mL/min; injection-specific excipient restriction
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-09

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Injection is contraindicated at CrCl below 30 mL/min. At CrCl 30-59 or 60-89 mL/min, no adjustment is required, but caution remains necessary. The renal concern includes hydroxypropyl-beta-cyclodextrin, the injection excipient. Obtain CrCl before treatment and monitor during therapy. Do not substitute the capsule no-adjustment statement for IV eligibility.

RDM54-rxlist-tecovirimat-tpoxx-iv-3c7be644e4-C1 · Source locator: Dosage and Administration; Renal Impairment; selected Warnings and Precautions

Source-specific limits

Selected sections only. Source mirror and underlying label are not independent confirmations.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/tpoxx-drug/
Retrieved
2026-09-09
Renal-function method
CrCl, mL/min; injection-specific excipient restriction
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
fd9426e969cf84fe6582a4f3b69e111d0bf05acdfe2455d1dc7d7650988b11d4

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/tpoxx-drug/
Source retrieval
2026-09-09. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
c4eb80b8dcc3ca6dc2f07c6d7acc29e62475b66e1db6635f63c6da402f92fc49
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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