GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Rivaroxaban (Xarelto)

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Historical source

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Product / population
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Renal measure
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Historical source: not automatically current. Review current official labeling and separately attributed additions before use.

Historical indication-specific renal thresholds and recurrence-prevention regimen are not represented as current Xarelto labeling. Current labeling must be reviewed separately.

Original indications and adult dosing

Factor Xa inhibitor for nonvalvular atrial-fibrillation stroke/systemic-embolism prevention; DVT/PE treatment and recurrence prevention; and DVT prophylaxis after hip/knee replacement.

Take 15 and 20 mg tablets with food; 10 mg may be taken with or without food.

Nonvalvular AF: CrCl above 50 mL/min, 20 mg once daily with the evening meal; CrCl 15-50, 15 mg once daily with the evening meal.

Acute DVT/PE: 15 mg twice daily with food for 21 days, followed by 20 mg once daily with food. The historical source also gives 20 mg daily for long-term recurrence reduction.

Hip/knee-replacement prophylaxis: 10 mg once daily. The source lists 10, 15 and 20 mg tablets.

Renal Dosing and monitoring

Nonvalvular AF: avoid below CrCl 15; increased exposure is expected. Assess renal function periodically and more frequently when deterioration is possible. Discontinue if acute renal failure develops.

For DVT/PE treatment/recurrence prevention and hip/knee-replacement prophylaxis, this historical page says to avoid below CrCl 30 because of increased exposure/effect. For postoperative prophylaxis at CrCl 30-50, closely evaluate signs of blood loss. Discontinue for acute renal failure.

Hemodialysis

The original source says to avoid.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/rivaroxaban-xarelto/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Preserved GlobalRPh source

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Retrieved: 2026-09-05

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Renal dosing and precautions

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Historical indication-specific renal thresholds and recurrence-prevention regimen are not represented as current Xarelto labeling. Current labeling must be reviewed separately.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/rivaroxaban-xarelto/

Original indications and adult dosing

Factor Xa inhibitor for nonvalvular atrial-fibrillation stroke/systemic-embolism prevention; DVT/PE treatment and recurrence prevention; and DVT prophylaxis after hip/knee replacement.

Take 15 and 20 mg tablets with food; 10 mg may be taken with or without food.

Nonvalvular AF: CrCl above 50 mL/min, 20 mg once daily with the evening meal; CrCl 15-50, 15 mg once daily with the evening meal.

Acute DVT/PE: 15 mg twice daily with food for 21 days, followed by 20 mg once daily with food. The historical source also gives 20 mg daily for long-term recurrence reduction.

Hip/knee-replacement prophylaxis: 10 mg once daily. The source lists 10, 15 and 20 mg tablets.

GRPH-rivaroxaban-xarelto-01 · Source section: Original indications and adult dosingRenal section finder

Renal Dosing and monitoring

Nonvalvular AF: avoid below CrCl 15; increased exposure is expected. Assess renal function periodically and more frequently when deterioration is possible. Discontinue if acute renal failure develops.

For DVT/PE treatment/recurrence prevention and hip/knee-replacement prophylaxis, this historical page says to avoid below CrCl 30 because of increased exposure/effect. For postoperative prophylaxis at CrCl 30-50, closely evaluate signs of blood loss. Discontinue for acute renal failure.

GRPH-rivaroxaban-xarelto-02 · Source section: Renal Dosing and monitoringRenal section finder

Hemodialysis

The original source says to avoid.

GRPH-rivaroxaban-xarelto-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/rivaroxaban-xarelto/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
ab36b1216ce744e80d1a1e720cdd32428fae8caf81535f7e5de0dcb196f3d59e
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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